Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life.

Obesity (Silver Spring, Md.) Pub Date : 2025-07-23 DOI:10.1002/oby.24344

Ying Hu, Hao Ma, Xuan Wang, Shuqi Zhu, Danqing Chen, Zhaoxia Liang

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Abstract

Objective: Our objective was to assess the prospective association between breastfeeding and the risk of type 2 diabetes (T2D) in offspring and to investigate the joint effects of breastfeeding and genetic susceptibility on T2D risk.

Methods: We included 364,562 participants free from prevalent T2D from the UK Biobank. Cox proportional hazards models were employed to evaluate the association between breastfeeding and incident T2D.

Results: Over a median follow-up of 12 years, 12,795 cases of incident T2D were recorded. Ever breastfeeding was associated with a significantly lower risk of T2D compared with never breastfeeding (hazard ratio = 0.94, 95% CI: 0.89-0.99). Additionally, significant interaction effects on T2D risk were observed between breastfeeding and T2D genetic risk score (T2D-GRS), both multiplicatively and additively. The association between T2D-GRS and risk of T2D was stronger in participants who were never breastfed compared with those who were breastfed (p for multiplicative interaction = 0.040). The risk of T2D associated with never breastfeeding combined with a high T2D-GRS was greater than the sum of the risks associated with each individual factor (p for additive interaction = 0.007).

Conclusions: Breastfeeding is associated with a lower risk of incident T2D in offspring, showing both multiplicative and additive interactions with T2D-GRS.

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母乳喂养、遗传易感性和后代晚年2型糖尿病的关系。

目的：我们的目的是评估母乳喂养与后代2型糖尿病（T2D）风险之间的前瞻性关联，并研究母乳喂养和遗传易感性对T2D风险的共同影响。方法：我们纳入了来自UK Biobank的364,562名无流行T2D的参与者。采用Cox比例风险模型评估母乳喂养与T2D发生之间的关系。结果：在中位随访12年期间，记录了12,795例T2D事件。与从未母乳喂养相比，曾经母乳喂养与T2D风险显著降低相关（风险比= 0.94,95% CI: 0.89-0.99）。此外，观察到母乳喂养和T2D遗传风险评分（T2D- grs）对T2D风险的显著交互作用，无论是乘法还是加法。与母乳喂养的参与者相比，从未母乳喂养的参与者T2D- grs与T2D风险之间的关联更强（p为乘法交互作用= 0.040）。从不母乳喂养合并高T2D- grs的T2D风险大于与每个单独因素相关的风险之和（加性相互作用p = 0.007）。结论：母乳喂养与后代发生T2D的风险较低有关，显示出与T2D- grs的乘法和加法相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity (Silver Spring, Md.)

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