New amino-naphthoic acid derivatives produced by biological transformation using the deep-sea-derived bacterium Serinicoccus marinus KDM482.

IF 2.7 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2025-07-23 DOI:10.1038/s41429-025-00845-4

Mai Sakaguchi, Katsuki Kikuchi, Ryota Okamura, Akito Taniguchi, Kenichiro Nagai, Reiko Seki, Masashi Ando, Teruyoshi Tanaka, Takashi Fukuda

引用次数: 0

Abstract

Deep-sea-derived microorganisms are quite attractive as resources for new secondary metabolites, enzymes, and gene discovery. We have isolated many marine microorganisms from deep-sea creatures and screened the new secondary metabolites produced by them. Two new molecules designated amino-naphthoic acid derivatives (1 and 2) were obtained by biological transformation using the deep-sea derived bacterium Serinicoccus marinus KDM482 successfully. Structural analysis using 1D and 2D NMR and MS data revealed that both 1 and 2 were dimerized compounds of 3-amino-2-naphthoic acid. In biological assays, 1 and 2 moderately inhibited the growth of Malme-3M cells.

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深海来源的海洋丝氨酸球菌KDM482生物转化制备新的氨基萘衍生物。

深海微生物是发现新的次生代谢物、酶和基因的重要资源。我们从深海生物中分离出许多海洋微生物，并筛选了它们产生的新的次生代谢物。利用深海衍生的海洋丝氨酸球菌KDM482进行生物转化，成功获得了两个新的氨基萘衍生物（1和2）。通过1D和2D NMR和MS数据进行结构分析，发现1和2都是3-氨基-2-萘酸的二聚体化合物。在生物实验中，1和2适度抑制Malme-3M细胞的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.