Estimation of Vitamin B12 level and serum iron in OSMF patients-A case-controlled study.

Q3 Medicine

Journal of Oral and Maxillofacial Pathology Pub Date : 2025-04-01 Epub Date: 2025-06-30 DOI:10.4103/jomfp.jomfp_316_24

Samadrita Paul, Balaji Pachipulusu, Chandra Poornima, Govindraju Poornima, H C Girish, V K Varsha

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引用次数: 0

Abstract

Aim: To estimate the Vitamin B12 level and serum iron levels in Oral Submucous Fibrosis patients as compared to healthy individuals.

Materials and methods: Out of the total forty (40) participants, twenty had positive history for tobacco chewing (cases) with burning sensations, blanching, stiffness of the oral mucosa and reduced mouth opening. The other twenty participants were healthy individuals (controls) in the same age and gender. Serum iron and vitamin B12 profile has been estimated in all individuals to compare and correlate between cases and controls.

Results: Vitamin B12 levels were decreased in Oral Submucous Fibrosis and were found to be statistically significant (P = 0.014) as compared to healthy controls. A significant correlation was also found between the serum iron level in case group which is in significant moderate positive correlation (ρ =0.57) with vitamin B12, and it is statistically significant (P = 0.009) whereas in control group too serum iron level is also in significant moderate positive correlation (ρ =0.72) with vitamin B12, and it is statistically significant (P ≤ 0.001).

Conclusion: Serum vitamin B12 and iron levels in OSMF patients is significantly reduced and can be considered as a reliable biochemical indicator and may help in early diagnosis and prognosis.

查看原文本刊更多论文

OSMF患者维生素B12水平和血清铁的测定——一项病例对照研究。

目的：比较口腔黏膜下纤维化患者与健康人的维生素B12水平和血清铁水平。材料和方法：在总共40名参与者中，20名有咀嚼烟草的阳性史（例），有灼烧感、发白、口腔黏膜僵硬和开口缩小。其他20名参与者是相同年龄和性别的健康个体（对照组）。对所有个体的血清铁和维生素B12水平进行了估计，以比较病例和对照之间的相关性。结果：与健康对照组相比，口腔黏膜下纤维化组维生素B12水平降低，差异有统计学意义（P = 0.014）。病例组血清铁水平与维生素B12呈显著的中度正相关（ρ =0.57），有统计学意义（P = 0.009）；对照组血清铁水平与维生素B12也呈显著的中度正相关（ρ =0.72），有统计学意义（P≤0.001）。结论：OSMF患者血清维生素B12和铁水平明显降低，可作为可靠的生化指标，有助于早期诊断和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral and Maxillofacial Pathology Medicine-Otorhinolaryngology

CiteScore

1.40

自引率

0.00%

发文量

115

期刊介绍： The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.