Correlation of the WPOI and clinicopathological parameters in tongue OSCC patients.

Q3 Medicine

Journal of Oral and Maxillofacial Pathology Pub Date : 2025-04-01 Epub Date: 2025-06-30 DOI:10.4103/jomfp.jomfp_6_25

Priyadharshini Muthumanickam, Gheena Sukumaran, Pratibha Ramani

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引用次数: 0

Abstract

Background: Oral squamous cell carcinoma (OSCC) is the third most common head and neck malignancy, with tongue squamous cell carcinoma (TSCC) being highly aggressive due to its vascular and lymphatic supply. This study examines the correlation between the worst pattern of invasion (WPOI) and Ki-67 expression in TSCC to improve prognosis and treatment strategies.

Materials and methods: A retrospective analysis of 51 TSCC specimens (2021-2024) assessed clinicopathological data, WPOI classification, and Ki-67 expression using immunohistochemistry. Statistical correlations were evaluated.

Results: The study showed a male predominance (mean age 53 years), with non-healing ulcers on the lateral tongue as the most common presentation. High-risk WPOI patterns correlated with advanced disease and metastasis (P < 0.001). Ki-67 expression averaged 45% in aggressive cases, but no significant correlation was found between WPOI and extranodal extension.

Conclusion: WPOI and Ki-67 are crucial markers for TSCC aggressiveness, aiding in risk stratification and personalized treatment. Further validation in larger cohorts is needed.

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舌鳞癌患者WPOI与临床病理参数的相关性研究。

背景：口腔鳞状细胞癌（OSCC）是第三大最常见的头颈部恶性肿瘤，其中舌鳞状细胞癌（TSCC）由于其血管和淋巴供应而具有高度侵袭性。本研究旨在探讨TSCC中最坏侵袭模式（WPOI）与Ki-67表达的相关性，以改善预后和治疗策略。材料和方法：回顾性分析51例TSCC标本（2021-2024）的临床病理资料、WPOI分类和免疫组织化学Ki-67表达。评估统计相关性。结果：该研究显示男性优势（平均年龄53岁），舌侧未愈合溃疡是最常见的表现。高风险WPOI模式与晚期疾病和转移相关（P < 0.001）。Ki-67在侵袭性病例中的平均表达量为45%，但WPOI与结外扩张无显著相关性。结论：WPOI和Ki-67是判断TSCC侵袭性的重要指标，有助于风险分层和个性化治疗。需要在更大的队列中进一步验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral and Maxillofacial Pathology Medicine-Otorhinolaryngology

CiteScore

1.40

自引率

0.00%

发文量

115

期刊介绍： The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.