Short-Chain Polychlorinated Alkanes Exposure and Risk of Thyroid Cancer in a Population-Based Case-Control Study

IF 6.3

Environment & Health Pub Date : 2025-05-02 DOI:10.1021/envhealth.5c00044

Mei Liu, Xiaoling Guan, Lingling Meng*, Gaoxin Zhang, Jiyan Liu, Yingming Li*, Mary E. Turyk, An Li, Qinghua Zhang and Guibin Jiang,

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Abstract

Exposure to short-chain polychlorinated alkanes (PCAs-C_10–13) can disturb thyroid homeostasis, warranting an in-depth analysis of their relationship with thyroid risk and related clinical parameters. This study recruited and obtained serum samples from 478 participants in Shandong, China, including 240 thyroid cancer patients and 238 healthy controls. PCAs-C₁₀ presented as the predominant homologues in both case and control groups. PCAs-C_10–13 exposure displayed an essential role in thyroid cancer risk, in which a nonlinear dose-risk relationship was observed for PCAs-C_10–13, with PCAs-C₁₂ and PCAs-C₁₃ exhibiting significantly reduced risks (odds ratios < 1) for thyroid cancer. Specific PCAs-C_10–13 homologues were significantly associated with triglycerides, cholesterol, low-density lipoprotein cholesterol, and total lipid in the control group. Weighted quantile sum regression and Bayesian kernel machine regression revealed predominantly negative combined effects of PCAs-C_10–13 exposure on thyroid cancer, thyroid hormone, and serum lipid parameters. Our results showed that exposure to the current environmental level of PCAs-C_10–13 cannot heighten risks of thyroid cancer. Overall, this study first provides epidemiological evidence on the potential implications of PCAs-C_10–13 exposure and thyroid cancer risk.

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在一项基于人群的病例对照研究中，短链多氯代烷烃暴露与甲状腺癌的风险

暴露于短链多氯代烷烃（PCAs-C10-13）可扰乱甲状腺稳态，有必要深入分析其与甲状腺风险和相关临床参数的关系。本研究在中国山东招募并获得了478名参与者的血清样本，其中包括240名甲状腺癌患者和238名健康对照者。在病例组和对照组中，PCAs-C10都是主要的同源物。PCAs-C10-13暴露在甲状腺癌风险中发挥了重要作用，其中PCAs-C10-13存在非线性剂量-风险关系，PCAs-C12和PCAs-C13患甲状腺癌的风险显著降低（优势比< 1）。在对照组中，特异性PCAs-C10-13同系物与甘油三酯、胆固醇、低密度脂蛋白胆固醇和总脂质显著相关。加权分位数和回归和贝叶斯核机回归显示，PCAs-C10-13暴露对甲状腺癌、甲状腺激素和血脂参数的联合负影响显著。我们的研究结果表明，暴露于当前环境水平的PCAs-C10-13不会增加甲状腺癌的风险。总体而言，本研究首次提供了PCAs-C10-13暴露与甲状腺癌风险潜在影响的流行病学证据。

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来源期刊

Environment & Health 环境科学、健康科学-

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期刊介绍： Environment & Health a peer-reviewed open access journal is committed to exploring the relationship between the environment and human health.As a premier journal for multidisciplinary research Environment & Health reports the health consequences for individuals and communities of changing and hazardous environmental factors. In supporting the UN Sustainable Development Goals the journal aims to help formulate policies to create a healthier world.Topics of interest include but are not limited to:Air water and soil pollutionExposomicsEnvironmental epidemiologyInnovative analytical methodology and instrumentation (multi-omics non-target analysis effect-directed analysis high-throughput screening etc.)Environmental toxicology (endocrine disrupting effect neurotoxicity alternative toxicology computational toxicology epigenetic toxicology etc.)Environmental microbiology pathogen and environmental transmission mechanisms of diseasesEnvironmental modeling bioinformatics and artificial intelligenceEmerging contaminants (including plastics engineered nanomaterials etc.)Climate change and related health effectHealth impacts of energy evolution and carbon neutralizationFood and drinking water safetyOccupational exposure and medicineInnovations in environmental technologies for better healthPolicies and international relations concerned with environmental health