Extracellular DNA, hyaluronic acid, HIF pathways, and LncRNAs as predictive biomarkers of severe COVID-19.

IF 4 3区医学 Q2 VIROLOGY

Virology Journal Pub Date : 2025-07-23 DOI:10.1186/s12985-025-02886-5

Evgen Dubrovskyi, Tetiana Drevytska, Alla Portnychenko, Victor Dosenko, Iryna Halabitska, Pavlo Petakh, Denis E Kainov, Oleksandr Kamyshnyi

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引用次数: 0

Abstract

The clinical course of COVID-19 ranges from mild symptoms to severe complications, and common laboratory markers such as D-dimer, ferritin, interleukin-6 (IL-6), and C-reactive protein (CRP) often do not accurately predict which patients will develop severe disease. In this study, we reviewed current literature and analyzed additional data to assess emerging biomarkers that may help identify high-risk cases earlier. These include circulating cell-free DNA (cfDNA) produced during neutrophil extracellular trap formation (NETosis), hyaluronic acid (HA), hypoxia-inducible factor (HIF) isoforms, and related long non-coding RNAs such as HAS2-AS1 and HIF1-AS1. Increased levels of cfDNA/NETs, HA, and elevated expression of HIF isoforms and their lncRNAs are closely associated with key features of severe COVID-19, including immune-related blood clotting, low oxygen levels, vascular damage, and chronic inflammation. These biomarkers show promise for use in risk assessment tools that could support earlier clinical decisions and improve outcomes in patients with COVID-19.

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细胞外DNA、透明质酸、HIF通路和lncrna作为严重COVID-19的预测性生物标志物

COVID-19的临床病程从轻微症状到严重并发症不等，常见的实验室标志物如d -二聚体、铁蛋白、白细胞介素-6 （IL-6）和c反应蛋白（CRP）往往不能准确预测哪些患者会发展为严重疾病。在本研究中，我们回顾了现有文献并分析了其他数据，以评估可能有助于早期识别高危病例的新兴生物标志物。这些包括中性粒细胞胞外陷阱形成（NETosis）过程中产生的循环无细胞DNA （cfDNA）、透明质酸（HA）、缺氧诱导因子（HIF）亚型和相关的长链非编码rna，如HAS2-AS1和HIF1-AS1。cfDNA/NETs、HA水平升高、HIF亚型及其lncrna表达升高与严重COVID-19的关键特征密切相关，包括免疫相关凝血、低氧水平、血管损伤和慢性炎症。这些生物标志物有望用于风险评估工具，以支持早期临床决策并改善COVID-19患者的预后。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.