Hepatitis C virus infection in blood donors in Santa Catarina, Brazil, 2010-2020.

IF 1.4 4区医学 Q3 HEMATOLOGY

Transfusion Medicine Pub Date : 2025-10-01 Epub Date: 2025-07-24 DOI:10.1111/tme.70004

Fabiana Schuelter-Trevisol, Gabriel Tadeu Ossani, Gabriel Oscar Cremona Parma, Daisson José Trevisol

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引用次数: 0

Abstract

Introduction: Hepatitis C is a silent disease characterised by a persistent inflammatory process in the liver. Since blood is the main route of transmission, the objective of this study was to estimate the positivity rate of hepatitis C virus (HCV) infection in blood donations from the Public Blood Network of the State of Santa Catarina and to analyse the temporal trend and spatial distribution of cases between 2010 and 2020.

Methods: This historical cohort study included blood donors who tested positive for HCV and donated blood at the service between January 1, 2010, and December 31, 2020.

Results: Out of a total of 1 316 605 blood donations, 782 new samples tested positive for HCV, corresponding to an overall positivity rate of 59.4 per 100 000 donations. The majority of HCV-positive donors were adults, male, of white skin colour, married, and had at least a secondary education. Most HCV-positive cases were found in the South and Coastal Regions of Santa Catarina, although municipalities with high positivity rates were observed across all macro-regions of the state.

Conclusions: The HCV positivity rate in blood donations from the Public Blood Network of the State of Santa Catarina demonstrated a downward trend over time, while maintaining sociodemographic characteristics similar to those reported in other regional studies. Furthermore, although HCV cases were reported in all macro-regions, the highest positivity rates occurred in the South, Alto Vale do Itajaí, Meio Oeste, Serra Catarinense, and Grande Oeste regions.

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2010-2020年巴西圣卡塔琳娜献血者丙型肝炎病毒感染情况

简介：丙型肝炎是一种隐性疾病，其特征是肝脏持续炎症。由于血液是主要传播途径，本研究的目的是估计圣卡塔琳娜州公共血液网络捐献的血液中丙型肝炎病毒（HCV）感染的阳性率，并分析2010年至2020年期间病例的时间趋势和空间分布。方法：本历史队列研究纳入了2010年1月1日至2020年12月31日期间丙型肝炎病毒检测呈阳性并在服务中心献血的献血者。结果：在总共1316605次献血中，有782个新样本检测出HCV阳性，相当于每10万次献血的总阳性率为59.4。大多数hcv阳性献血者为成年男性，白皮肤，已婚，至少受过中等教育。大多数hcv阳性病例出现在圣卡塔琳娜州的南部和沿海地区，尽管在该州所有大区域都观察到高阳性率的城市。结论：圣卡塔琳娜州公共血液网络献血中的HCV阳性率随着时间的推移呈下降趋势，同时保持与其他区域研究报告相似的社会人口统计学特征。此外，尽管在所有大区域都报告了HCV病例，但最高的阳性率发生在南部、Alto Vale do Itajaí、Meio Oeste、Serra Catarinense和Grande Oeste地区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transfusion Medicine 医学-血液学

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Transfusion Medicine publishes articles on transfusion medicine in its widest context, including blood transfusion practice (blood procurement, pharmaceutical, clinical, scientific, computing and documentary aspects), immunohaematology, immunogenetics, histocompatibility, medico-legal applications, and related molecular biology and biotechnology. In addition to original articles, which may include brief communications and case reports, the journal contains a regular educational section (based on invited reviews and state-of-the-art reports), technical section (including quality assurance and current practice guidelines), leading articles, letters to the editor, occasional historical articles and signed book reviews. Some lectures from Society meetings that are likely to be of general interest to readers of the Journal may be published at the discretion of the Editor and subject to the availability of space in the Journal.