Quantitative ophthalmic posterior segment optical coherence tomography angiography and systemic conditions.

IF 5.1 2区医学 Q1 OPHTHALMOLOGY

Survey of ophthalmology Pub Date : 2025-07-21 DOI:10.1016/j.survophthal.2025.07.005

Michael Drakopoulos, Arnold Nadel, Harnaina K Bains, Jay B Bisen, Hayden Sikora, Kevin X Zhang, Alessandro Marchese, Joseph Fahey, Rukhsana G Mirza

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Abstract

Optical coherence tomography angiography (OCTA) non-invasively and quantitatively images the microvasculature of the eye's posterior segment in 3 dimensions. OCTA has known utility in the diagnosis and management of certain ocular conditions and is now being used to assess systemic conditions, including respiratory, cardiovascular, renal, obstetric, neurologic, rheumatologic, and genetic conditions, among others. OCTA may improve our understanding of the pathophysiology of systemic conditions and identify biomarkers useful in their diagnosis, prognosis, and management. We detail known associations between quantitative retinal, optic nerve head, and choriocapillaris OCTA findings and clinically relevant features of systemic conditions, including laboratory markers and disease severity and prognosis. We find that the breadth and depth of such correlations solidify OCTA's role in the emerging field of oculomics, which seeks to identify ocular imaging biomarkers for use in the study and management of non-ocular conditions.

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定量眼后段光学相干断层血管造影和全身状况。

光学相干断层血管造影（OCTA）是一种无创、定量的三维图像技术。众所周知，OCTA在某些眼部疾病的诊断和管理方面具有实用价值，现在正被用于评估全身疾病，包括呼吸、心血管、肾脏、产科、神经、风湿病和遗传疾病等。OCTA可以提高我们对全身性疾病病理生理学的理解，并确定对其诊断、预后和管理有用的生物标志物。我们详细介绍了定量视网膜、视神经头和绒毛膜毛细血管的OCTA发现与系统性疾病的临床相关特征之间的关联，包括实验室标记物、疾病严重程度和预后。我们发现，这种相关性的广度和深度巩固了OCTA在新兴的眼组学领域中的作用，该领域旨在识别用于研究和管理非眼疾病的眼成像生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Survey of ophthalmology 医学-眼科学

CiteScore

10.30

自引率

2.00%

发文量

138

审稿时长

14.8 weeks

期刊介绍： Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.