Prognostic implications of complement C1q-like 4 expression in breast cancer.

IF 3.9 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Scientific Reports Pub Date : 2025-07-24 DOI:10.1038/s41598-025-12557-8

Qing Zhang, Zhijun Xing, Lu Bai, Xiao Li, Fan Xu

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Abstract

Higher expression of Complement C1q-like protein 4 (C1ql4) in breast cancer may be associated with increased tumor malignancy. As a protein involved in immune responses and inflammation, C1ql4 is expressed across all molecular subtypes of breast cancer. We conducted a retrospective analysis and follow-up study involving 111 patients who underwent breast cancer resection at the Department of Breast Surgery, Affiliated Hospital of Chengde Medical College, to investigate the relationship between C1ql4 expression and overall survival, as well as to evaluate the prognostic value of C1ql4 both independently and in combination with conventional clinicopathologic parameters. Chi-square analysis revealed a significant positive difference between C1ql4 protein expression and TNM staging, as well as molecular subtypes. Moreover, patients with high C1ql4 expression demonstrated significantly poorer prognoses. In conclusion, our findings suggest that C1ql4 expression may serve as a potential biomarker for elevated breast cancer malignancy.

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补体c1q -样4表达在乳腺癌中的预后意义。

补体c1q样蛋白4 （C1ql4）在乳腺癌中的高表达可能与肿瘤恶性程度增加有关。作为一种参与免疫反应和炎症的蛋白质，C1ql4在乳腺癌的所有分子亚型中表达。我们对111例在承德医学院附属医院乳腺外科行乳腺癌切除术的患者进行回顾性分析和随访研究，探讨C1ql4表达与总生存的关系，并评价C1ql4独立表达和结合常规临床病理参数的预后价值。卡方分析显示，C1ql4蛋白表达与TNM分期及分子亚型之间存在显著正相关差异。此外，C1ql4高表达患者的预后明显较差。总之，我们的研究结果表明，C1ql4的表达可能是乳腺癌恶性肿瘤升高的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scientific Reports Natural Science Disciplines-

CiteScore

7.50

自引率

4.30%

发文量

19567

审稿时长

3.9 months

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