A core outcome set for pituitary surgery research: an international delphi consensus study.

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Pituitary Pub Date : 2025-07-23 DOI:10.1007/s11102-025-01553-w

Alexandra Valetopoulou, Nicola Newall, Danyal Z Khan, Anouk Borg, Pierre M G Bouloux, Fion Bremner, Michael Buchfelder, Simon Cudlip, Neil Dorward, William M Drake, Juan C Fernandez-Miranda, Maria Fleseriu, Mathew Geltzeiler, Joy Ginn, Mark Gurnell, Steve Harris, Zane Jaunmuktane, Márta Korbonits, Michael Kosmin, Olympia Koulouri, Hugo Layard Horsfall, Adam N Mamelak, Richard Mannion, Pat McBride, Ann I McCormack, Shlomo Melmed, Katherine A Miszkiel, Gerald Raverot, Thomas Santarius, Theodore H Schwartz, Inma Serrano, Gabriel Zada, Stephanie E Baldeweg, Hani J Marcus, Angelos G Kolias

{"title":"A core outcome set for pituitary surgery research: an international delphi consensus study.","authors":"Alexandra Valetopoulou, Nicola Newall, Danyal Z Khan, Anouk Borg, Pierre M G Bouloux, Fion Bremner, Michael Buchfelder, Simon Cudlip, Neil Dorward, William M Drake, Juan C Fernandez-Miranda, Maria Fleseriu, Mathew Geltzeiler, Joy Ginn, Mark Gurnell, Steve Harris, Zane Jaunmuktane, Márta Korbonits, Michael Kosmin, Olympia Koulouri, Hugo Layard Horsfall, Adam N Mamelak, Richard Mannion, Pat McBride, Ann I McCormack, Shlomo Melmed, Katherine A Miszkiel, Gerald Raverot, Thomas Santarius, Theodore H Schwartz, Inma Serrano, Gabriel Zada, Stephanie E Baldeweg, Hani J Marcus, Angelos G Kolias","doi":"10.1007/s11102-025-01553-w","DOIUrl":null,"url":null,"abstract":"Purpose: This study aimed to develop a core outcome set (COS) for pituitary surgery to enhance the quality, efficiency and effectiveness of future pituitary adenoma surgery research.Methods: Thirty-three outcomes were identified through a systematic review of pituitary adenoma surgery outcomes and a study on patient-reported measures. These were presented in an online survey to healthcare professionals (HCPs), patients and caregivers. In the first round, participants scored each outcome's importance on a 5-point scale (1-strongly disagree; 5-strongly agree) and could also suggest additional outcomes, which were reviewed and, if appropriate, added to existing domains. In the second round, participants re-scored the updated the list, considering group median and interquartile range scores from the previous round. Outcomes with a median score of 5 were included in the COS. A final live online consensus meeting discussed and voted on borderline outcomes (median scores 3-4).Results: The first round received 95 responses (52% HCPs, 48% patients/caregivers). Of the 33 outcomes, 16 received a median score of 5 (strongly agree), three received 4.5 and 14 received 4 (agree). Round two received 87 responses (52% HCPs, 48% patients and caregivers). Of the 33 outcomes, 14 received a median ranking of 5, two received 4.5, 15 received 4 and two received 3 (neutral). The live meeting (attended by 12 participants: 5 HCPs, 6 patients, 1 caregiver), reached consensus on the final COS, which includes 7 domains: short-term surgical outcomes; nasal outcomes; ophthalmic outcomes; endocrine outcomes; quality of life and psychological outcomes; other short-term outcomes; and disease control outcomes.Conclusion: We advocate for use of the COS in future pituitary surgery research.","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"28 4","pages":"88"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287136/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pituitary","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11102-025-01553-w","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This study aimed to develop a core outcome set (COS) for pituitary surgery to enhance the quality, efficiency and effectiveness of future pituitary adenoma surgery research.

Methods: Thirty-three outcomes were identified through a systematic review of pituitary adenoma surgery outcomes and a study on patient-reported measures. These were presented in an online survey to healthcare professionals (HCPs), patients and caregivers. In the first round, participants scored each outcome's importance on a 5-point scale (1-strongly disagree; 5-strongly agree) and could also suggest additional outcomes, which were reviewed and, if appropriate, added to existing domains. In the second round, participants re-scored the updated the list, considering group median and interquartile range scores from the previous round. Outcomes with a median score of 5 were included in the COS. A final live online consensus meeting discussed and voted on borderline outcomes (median scores 3-4).

Results: The first round received 95 responses (52% HCPs, 48% patients/caregivers). Of the 33 outcomes, 16 received a median score of 5 (strongly agree), three received 4.5 and 14 received 4 (agree). Round two received 87 responses (52% HCPs, 48% patients and caregivers). Of the 33 outcomes, 14 received a median ranking of 5, two received 4.5, 15 received 4 and two received 3 (neutral). The live meeting (attended by 12 participants: 5 HCPs, 6 patients, 1 caregiver), reached consensus on the final COS, which includes 7 domains: short-term surgical outcomes; nasal outcomes; ophthalmic outcomes; endocrine outcomes; quality of life and psychological outcomes; other short-term outcomes; and disease control outcomes.

Conclusion: We advocate for use of the COS in future pituitary surgery research.

Abstract Image

查看原文本刊更多论文

垂体外科研究的核心结果集：一项国际德尔菲共识研究。

目的：本研究旨在建立垂体手术的核心结局集（COS），以提高垂体腺瘤手术研究的质量、效率和效果。方法：通过对垂体腺瘤手术结果的系统回顾和对患者报告措施的研究，确定了33个结果。这些结果以在线调查的形式呈现给医疗保健专业人员（HCPs）、患者和护理人员。在第一轮中，参与者以5分制(1-非常不同意；（强烈同意），也可以提出额外的结果，这些结果经过审查，如果合适的话，可以添加到现有的领域。在第二轮中，参与者根据前一轮的组中值和四分位数范围分数，对更新后的列表重新打分。中位评分为5分的结果纳入COS。最后的现场在线共识会议讨论和投票的边缘结果（中位数得分3-4）。结果：第一轮共收到95份反馈（52%的HCPs， 48%的患者/护理人员）。在33个结果中，16个得到5分（非常同意），3个得到4.5分，14个得到4分（同意）。第二轮收到87份回复（52%的医护人员，48%的患者和护理人员）。在33个结果中，14个获得5分，2个获得4.5分，15个获得4分，2个获得3分（中性）。现场会议（12人参加：5名HCPs， 6名患者，1名护理人员）就最终COS达成了共识，其中包括7个领域：短期手术结果；鼻的结果;眼科的结果;内分泌的结果;生活质量和心理结果；其他短期结果；以及疾病控制的结果。结论：我们提倡在今后的垂体外科研究中使用COS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Pituitary 医学-内分泌学与代谢

CiteScore

7.10

自引率

7.90%

发文量

审稿时长

6 months

期刊介绍： Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease. The journal considers: Biology of Pituitary Tumors Mechanisms of Pituitary Hormone Secretion Regulation of Pituitary Function Prospective Clinical Studies of Pituitary Disease Critical Basic and Clinical Reviews Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.