Airway Mucus Plugs in Patients with Chronic Cough: A Single-Center Observational Study.

IF 3.9 2区医学 Q1 RESPIRATORY SYSTEM

Lung Pub Date : 2025-07-24 DOI:10.1007/s00408-025-00839-x

Kyongmin Sarah Beck, Dae Hee Han, Hyun-Seob Jeon, Juyoung Shin, Sook Young Lee, Woo-Jung Song, Hwa Young Lee

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引用次数: 0

Abstract

Background: This study investigated the prevalence of mucus plugs and their clinical associations in patients with chronic cough.

Methods: Chest computed tomography (CT) scans were evaluated in patients with chronic cough and healthy controls.

Results: Among 82 patients with chronic cough and 71 controls, mucus plugs were identified in 31.7% and 5.6%, respectively. Higher mucus plug scores were associated with older age, elevated fractional exhaled nitric oxide (FeNO), and lower total Cough Hypersensitivity Questionnaire (CHQ) scores (all P < 0.05). Regression analysis revealed associations with higher FeNO and lower total CHQ scores (Model 1: R² = 0.396, P < 0.001), and with higher immunoglobulin (Ig) E levels (Model 2: R² = 0.388, P < 0.001). Mucus plug scores did not differ by 1-month treatment response.

Conclusions: Mucus plugs were prevalent in chronic cough and associated with type 2 airway inflammation. Their clinical significance warrants further investigation.

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慢性咳嗽患者的气道粘液塞：一项单中心观察研究。

背景：本研究调查了慢性咳嗽患者粘液塞的患病率及其临床相关性。方法：对慢性咳嗽患者和健康对照者进行胸部CT扫描。结果：82例慢性咳嗽患者和71例对照组中，痰塞检出率分别为31.7%和5.6%。黏液塞评分越高，年龄越大，呼出一氧化氮分数（FeNO）越高，咳嗽超敏反应问卷（CHQ）总分越低（均P = 0.396, P = 0.388， P）。结论：黏液塞常见于慢性咳嗽，并与2型气道炎症相关。其临床意义值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lung 医学-呼吸系统

CiteScore

9.10

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.