Unmet needs in the pharmacological management of motor symptoms in Parkinson's disease.

IF 5 3区 医学 Q2 NEUROSCIENCES
Beatrice Heim, Werner Poewe
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引用次数: 0

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder clinically defined by the presence of cardinal motor features like bradykinesia, rigidity and resting tremor. The mainstay of PD treatment is pharmacological dopamine substitution and responsiveness of motor symptoms to levodopa is a supporting diagnostic feature of this illness. Although the armentarium of drugs to treat the motor symptoms of PD and their efficacy on a variety of motor problems are overall impressive, significant unmet needs persist, particularly in the advanced stages of PD. These include situations of poorly responsive tremor, motor complications associated with sustained levodopa exposure, disorders of gait and balance as well as impairments of posture, speech and swallowing. This review provides an overview of available treatment strategies for these areas of unmet need and emerging therapies under development. Future perspectives include novel pharmacological targets, new modes of drug delivery, combination therapies and the integration of real-time monitoring and wearable technologies to tailor treatments.

帕金森病运动症状药理学治疗中未满足的需求
帕金森病(PD)是一种进行性神经退行性疾病,临床表现为运动迟缓、强直和静息性震颤等主要运动特征。帕金森病的主要治疗方法是药物多巴胺替代,运动症状对左旋多巴的反应性是该疾病的一个支持性诊断特征。尽管治疗帕金森病运动症状的药物种类及其对各种运动问题的疗效总体上令人印象深刻,但仍有大量未满足的需求,特别是在帕金森病的晚期。这些情况包括反应性差的震颤、与持续左旋多巴接触相关的运动并发症、步态和平衡障碍以及姿势、语言和吞咽障碍。本综述概述了这些领域未满足需求的可用治疗策略和正在开发的新兴治疗方法。未来的前景包括新的药理靶点,新的药物传递模式,联合疗法以及实时监测和可穿戴技术的整合,以定制治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.40
自引率
5.80%
发文量
338
审稿时长
>12 weeks
期刊介绍: The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.
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