Targeting TNF-α: An immunotherapeutic approach for alleviating neuropathic pain.

Abstract

Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a key role in regulating immune responses. It is primarily produced by activated macrophages but also by other cell types, including T lymphocytes and natural killer (NK) cells. TNF-α is involved in many physiological processes, including cell proliferation and differentiation. Furthermore, TNF-α has been associated with the development of many inflammatory and autoimmune diseases. Recent studies have underscored the critical role of TNF-α in neuropathic pain, a complex and frequently debilitating condition resulting from nerve injury or dysfunction. Increased levels of TNF-α in the nervous system have been associated with the development of neuropathic pain, contributing to neuronal sensitization and altered pain pathways. This fact positions TNF-α as a potential therapeutic target for pain management. The efficacy of targeting TNF-α in neuropathic pain has been evaluated via preclinical and clinical models. Preclinical studies have shown that administering anti-TNF-α antibodies can reduce pain behaviors and inflammation, suggesting a promising therapeutic approach. Current clinical trials are being conducted to evaluate the effectiveness of anti-TNF-α therapies, with promising results in patients with neuropathic pain.