Maximizing the therapeutic benefits of biopolymer-derived nanoparticles in wound healing.

Abstract

Nanoparticles have emerged as a cornerstone of nanomedicine, offering transformative potential to modern healthcare through their multifunctional capabilities. Their adaptability positions them as ideal candidates for wound management, either as advanced wound dressings or as efficient drug delivery systems. With intrinsic antibacterial properties and the ability to enhance tissue repair, nanoparticles have gained significant attention in promoting effective wound healing. Biopolymer-based nanoparticles, derived from naturally sourced and synthetic materials such as proteins, polysaccharides, and polymers, including collagen, chitosan, alginate, polycaprolactone, and polylactic acid, stand out due to their unique combination of biodegradability and biocompatibility. These attributes make them particularly suited for addressing the challenges of wound care. Moreover, nanofibers incorporated with biopolymer-based nanoparticles demonstrate superior antibacterial properties and wound healing effectiveness, comparable to the performance of silver nanoparticles. These advancements signify a transformative approach in wound healing therapies, facilitating targeted and personalized treatments that expedite tissue regeneration and enhance patient recovery. This review delves into biopolymer-based nanoparticles' advancements, applications, and potential in revolutionizing wound healing.