Coronal lumbar horizontal shift and lower limb force line in patients with knee osteoarthritis: a correlation study.

IF 4.3 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Frontiers in Bioengineering and Biotechnology Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1600020

Yong-Wang Zhang, Pei-Yu Du, Xi Li, Lu Liu, Yun-Tao Yan, Yi-Cong Bai, Xin-Yu Tian, Shuang-Qing Du

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Abstract

Objective: The aim of this study is to explore the correlation between the horizontal deviation of the coronal lumbar spine and the lower limb force line in knee osteoarthritis (KOA).

Methods: A retrospective analysis of 233 KOA cases (47 male patients and 186 female patients, aged 50-83 years, with an average of 61.55 ± 8.72 years) admitted from 1 October 2022 to 31 December 2023 was conducted. Bilateral hip, knee, and ankle (HKA) angles; mechanical axis offset distance (MAD); joint line convergence angle (JLCA); lumbar-knee offset distance (LKOD, a self-tested angle reflecting the difference in the position of the bilateral knee joint relative to the lumbar vertebra); Western Ontario and McMaster Universities Arthritis Index (WOMAC) score; and baseline data records were assessed for all patients.

Results: The WOMAC score was correlated with L1, L2, and L3 in LKOD (P < 0.05; r = 0.240, 0.362, and 0.386) but not with L4 and L5 (P > 0.05). WOMAC was also associated with HKA, MAD, and JLCA on the affected side (P < 0.05; r = -0.127, 0.140, and 0.135). The unaffected side and d-values were not associated with HKA, MAD, and JLCA (the d-value represents the absolute value of the difference between the unaffected and affected sides, which represents the overall change in both lower limbs) (P > 0.05). L1-L5 in LKOD was associated with HKA and MAD d-values (P < 0.05); LKOD was not correlated with HKA, MAD, and JLCA on the affected side.

Conclusion: Lumbar horizontal deviation is a risk factor affecting all angles in both lower limbs and may aggravate knee bone and joint symptoms. The influence of horizontal direction changes in the lumbar spine on KOA, especially change in L3, should be prioritized in the clinical treatment and research of KOA.

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膝关节骨性关节炎患者腰冠状位水平移位与下肢力线的相关性研究。

目的：探讨膝关节骨性关节炎（KOA）患者冠状腰椎水平偏移与下肢力线的相关性。方法：回顾性分析2022年10月1日至2023年12月31日收治的KOA患者233例（男47例，女186例，年龄50 ~ 83岁，平均61.55±8.72岁）。双侧髋关节、膝关节和踝关节（HKA）角度；机械轴偏移距离；节理线收敛角（JLCA）；腰膝偏移距离（LKOD，一个反映双侧膝关节相对于腰椎位置差异的自测角度）；西安大略和麦克马斯特大学关节炎指数（WOMAC）评分；并评估所有患者的基线数据记录。结果：WOMAC评分与LKOD的L1、L2、L3有相关性(P < 0.05；r = 0.240, 0.362, 0.386)，但与L4和L5无关（P < 0.05）。WOMAC还与患侧HKA、MAD、JLCA相关(P < 0.05；R = -0.127、0.140和0.135)。未患侧及d值与HKA、MAD、JLCA无相关性（d值为未患侧与患侧差异的绝对值，代表双下肢整体变化）（P > 0.05）。LKOD的L1-L5与HKA、MAD的d值相关（P < 0.05）；LKOD与患侧HKA、MAD、JLCA无相关性。结论：腰椎水平偏差是影响双下肢各角度的危险因素，可加重膝关节骨关节症状。腰椎水平方向的改变对KOA的影响，尤其是L3的改变，在KOA的临床治疗和研究中应优先考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.