Physician and patient perspectives on the treatment of hypercholesterolaemia: a cross-sectional study to identify disconnects.

IF 2.2 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Current Medical Research and Opinion Pub Date : 2025-07-01 Epub Date: 2025-08-08 DOI:10.1080/03007995.2025.2538748
Adie Viljoen, Vivian Auyeung, Holly Foot, Chloe Grimmett, Silvia Bodini, Laura Douglas, Tamara Kaloti, Zoe Moon, Richa Chhabra, Emma Cotterill, Daniel Robinson, Alberico Catapano, Leonardo De Luca, Tim Hollstein, Jules Payne, Matteo Pirro, Anja Vogt, Rob Horne
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引用次数: 0

Abstract

Objectives: Implementation of more stringent LDL-C targets, as recommended by ESC/EAS guidelines, may be influenced by physician understanding of patient preferences. We aimed to understand patient preferences for lipid lowering therapy (LLT) management, perceptions of LLT and unmet needs, alongside physician predictions. We also investigated physician and patient therapy choices in two clinical scenarios.

Methods: 450 physicians (224 primary care and 226 specialists) across Germany, Italy, and the UK were analysed.

Results: Patients reported a high prevalence of unmet needs in relation to support with treatment which was not apparent to physicians. Clinicians underestimated the proportion of patients with doubts about their perceived need for LLT (predicted 40%; actual 64%), treatment concerns (predicted 40%; actual 78.7%), and unmet information needs (32% physician agreement; actual 75%). Despite having negative attitudes to existing treatments, 82% of patients were open to treatment intensification if their LLT was suboptimal (vs. 55% physician agreement). Furthermore, only 16.7% of patients believed repeated prescription changes would lead to non-adherence (vs. 52.4% physician agreement). Presented with case studies, physicians chose progressive LLT more often for the high CV risk case with statin intolerance than for the very high CV risk uncontrolled case (82.7% vs. 61.6%). In both cases, approximately 50% of patients chose progressive LLT.

Conclusion: More comprehensive physician and patient support is needed to optimize LLT treatment. This should address patient and clinician barriers to treatment escalation and facilitate shared decision-making.

医生和患者对高胆固醇血症治疗的看法:一项横断面研究,以确定脱节。
目的:按照ESC/EAS指南的建议,实施更严格的LDL-C目标可能会受到医生对患者偏好的理解的影响。我们的目的是了解患者对降脂治疗(LLT)管理的偏好,对LLT的看法和未满足的需求,以及医生的预测。我们也调查了医生和病人在两种临床情况下的治疗选择。方法:对德国、意大利和英国的450名医生(224名初级保健医生和226名专科医生)进行了分析。结果:患者报告了与支持治疗相关的未满足需求的高患病率,这对医生来说并不明显。临床医生低估了怀疑自己感知到的LLT需求的患者比例(预测为40%;实际64%),治疗问题(预测40%;实际的78.7%)和未满足的信息需求(32%的医生同意;实际的75%)。尽管对现有治疗持负面态度,但82%的患者在LLT不理想的情况下接受强化治疗(相比之下,55%的医生同意)。此外,只有16.7%的患者认为反复改变处方会导致不依从(相比之下,52.4%的医生同意)。在案例研究中,医生更多地选择渐进式LLT治疗伴有他汀类药物不耐受的高危CV患者,而非高危CV不受控制的患者。(82.7%对61.6%)。在这两种情况下,大约50%的患者选择了进行性LLT。结论:优化LLT治疗需要更全面的医患支持。这应解决患者和临床医生对治疗升级的障碍,并促进共同决策。
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来源期刊
Current Medical Research and Opinion
Current Medical Research and Opinion 医学-医学:内科
CiteScore
4.40
自引率
4.30%
发文量
247
审稿时长
3-8 weeks
期刊介绍: Current Medical Research and Opinion is a MEDLINE-indexed, peer-reviewed, international journal for the rapid publication of original research on new and existing drugs and therapies, Phase II-IV studies, and post-marketing investigations. Equivalence, safety and efficacy/effectiveness studies are especially encouraged. Preclinical, Phase I, pharmacoeconomic, outcomes and quality of life studies may also be considered if there is clear clinical relevance
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