Association Between Gastroesophageal Reflux Disease and the Risk of Incident Chronic Obstructive Pulmonary Disease.

Q4 Medicine

中国医学科学院学报 Pub Date : 2025-06-30 DOI:10.3881/j.issn.1000-503X.16279

Ye Liao, Yun-Feng Zhou, Xiao-Rui Zhou, Xin Hu, Juan Liao, Lu Long

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引用次数: 0

Abstract

Objective To investigate the association between gastroesophageal reflux disease(GERD)and the risk of incident chronic obstructive pulmonary disease(COPD)and explore potential effect modifiers influencing this association.Methods Clinical data from 476 175 participants in the UK Biobank(2006-2010)were collected.A Cox proportional hazards model was used to assess the relationship between GERD and the risk of incident COPD.Subgroup analyses were conducted to examine potential modifiers of the primary findings.Results A total of 11 587(2.43%)new COPD cases were diagnosed.The Cox proportional hazards model revealed that GERD was associated with an increased risk of incident COPD(HR=1.59,95%CI=1.46-1.74,P<0.001).GERD was linked to a higher risk of incident COPD in individuals aged<60 years(P<0.001)and non-smokers(P=0.011).No association was observed between GERD and the risk of incident COPD in current smokers with a daily cigarette consumption<10 cigarettes(P=0.261).Conclusion GERD may increase the risk of incident COPD.

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胃食管反流病与慢性阻塞性肺疾病发生风险的关系

目的探讨胃食管反流病（GERD）与慢性阻塞性肺疾病（COPD）发生风险的关系，并探讨影响这种关系的潜在效应调节因子。方法收集英国生物银行（UK Biobank） 2006-2010年476 175名参与者的临床资料。采用Cox比例风险模型评估GERD与COPD发生风险之间的关系。进行亚组分析以检查初步发现的潜在修正因素。结果共确诊慢性阻塞性肺病新发病例11 587例（2.43%）。Cox比例风险模型显示，GERD与COPD发生风险增加相关（HR=1.59,95%CI=1.46-1.74，PPP=0.011）。在每日吸烟的吸烟者中，未观察到胃食管反流与COPD发病风险之间的关联（p =0.261）。结论胃食管反流可增加慢性阻塞性肺病的发生风险。

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来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].