Effective RNA Complexation by [2]Catenanes Confers Enhanced Resistance to Enzymatic Degradation

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-07-24 DOI:10.1002/chem.202501631

Dimitri Delcourt, Dr. José García Coll, Dr. Fabien B. L. Cougnon, Dr. Sébastien Ulrich

引用次数: 0

Abstract

Cationic [2]catenanes bearing l-arginine residues were synthesized via dynamic covalent self-assembly in water. These peptide-based mechanically interlocked molecules (MIMs) exhibit proteolytic stability, efficiently complex small-interfering RNA (siRNA), and protect it from nuclease degradation. Their performance in siRNA binding is attributed to multivalency and preorganization enforced by the mechanical bond.

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[2]链烷有效的RNA络合增强了酶降解的抵抗力。

采用动态共价自组装方法在水中合成了含l-精氨酸残基的阳离子[2]链烷。这些基于肽的机械联锁分子（mim）具有蛋白质水解稳定性，有效地复杂小干扰RNA (siRNA)，并保护其免受核酸酶降解。它们在siRNA结合中的表现归因于机械键强制的多价性和预组织。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

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