Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness.

IF 8 1区医学 Q1 CELL BIOLOGY

Aging Cell Pub Date : 2025-07-24 DOI:10.1111/acel.70151

Alper Cevirgel, Marieke van der Heiden, Sudarshan A Shetty, Markus Viljanen, Martijn Vos, Elske Bijvank, Yannick van Sleen, Celine Imhof, Joeri A J Rolwes, Leonard Daniël Samson, Lisa Beckers, Nynke Rots, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle

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引用次数: 0

Abstract

Immune aging is associated with decreased vaccine responses, but biomarkers for vaccine responsiveness remain unidentified. We analyzed immunotypes describing pre-vaccination immune cell profiles and their associations with triple vaccine responsiveness to influenza, pneumococcal, and SARS-CoV-2 vaccines in adults aged 25-78 years. Additionally, we developed an innovative measure, immune entropy, to quantify cumulative perturbations in the immune cell subset network. Specific immunotypes were associated with either weak or robust triple vaccine responsiveness. In addition, immune entropy was inversely related to vaccine responsiveness regardless of age. In a validation cohort of older adults, higher immune entropy was also associated with a lower antibody response to the BNT162b2 vaccine. A separate cohort of kidney transplant recipients, typically exhibiting diminished vaccine responses, demonstrated significantly increased immune entropy compared to healthy counterparts. Our findings suggest immunotypes and immune entropy as potential indicators to identify individuals at risk for suboptimal vaccine responses, potentially guiding personalized vaccination strategies.

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免疫前免疫型和免疫熵是多种疫苗反应性的指标。

免疫老化与疫苗反应降低有关，但疫苗反应的生物标志物仍未确定。我们分析了描述疫苗接种前免疫细胞谱的免疫类型及其与25-78岁成年人对流感、肺炎球菌和SARS-CoV-2疫苗的三联疫苗反应性的关系。此外，我们开发了一种创新的测量方法，免疫熵，以量化免疫细胞子集网络中的累积扰动。特异性免疫类型与弱或强的三联疫苗反应性相关。此外，无论年龄大小，免疫熵与疫苗反应性呈负相关。在老年人验证队列中，较高的免疫熵也与较低的抗体对BNT162b2疫苗的反应相关。另一组肾移植受者，通常表现出较弱的疫苗反应，与健康人相比，显示出显著增加的免疫熵。我们的研究结果表明，免疫类型和免疫熵可以作为潜在的指标来识别有次优疫苗反应风险的个体，从而潜在地指导个性化的疫苗接种策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Cell Biochemistry, Genetics and Molecular Biology-Cell Biology

自引率

2.60%

发文量

212

期刊介绍： Aging Cell is an Open Access journal that focuses on the core aspects of the biology of aging, encompassing the entire spectrum of geroscience. The journal's content is dedicated to publishing research that uncovers the mechanisms behind the aging process and explores the connections between aging and various age-related diseases. This journal aims to provide a comprehensive understanding of the biological underpinnings of aging and its implications for human health. The journal is widely recognized and its content is abstracted and indexed by numerous databases and services, which facilitates its accessibility and impact in the scientific community. These include: Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Biological Science Database (ProQuest) CAS: Chemical Abstracts Service (ACS) Embase (Elsevier) InfoTrac (GALE Cengage) Ingenta Select ISI Alerting Services Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) Natural Science Collection (ProQuest) PubMed Dietary Supplement Subset (NLM) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) Web of Science (Clarivate Analytics) Being indexed in these databases ensures that the research published in Aging Cell is discoverable by researchers, clinicians, and other professionals interested in the field of aging and its associated health issues. This broad coverage helps to disseminate the journal's findings and contributes to the advancement of knowledge in geroscience.