Innovative fabrication of a copper-infused MOF-NH2@Bentonite composite and using for swift and effective electrochemical detection of antidepressant trazodone

Abstract

This study presents an innovative developed approach to synthesizing a composite of Copper-Metal Organic Framework (Cu-MOF) using a simple one-step solvothermal technique, followed by amination with ethylenediamine (EDA). For the first time, this composite was integrated with Bentonite nanoparticles, a soft and porous rock powder, serving as an effective stabilizing platform. The composite's morphology and chemical characteristics were evaluated using various techniques, including FT-IR, SEM, EDX, and XRD. Moreover, the research resulted in the development of a reliable and cost-effective electrochemical sensor for the accurate detection of Trazodone (Trz), an antidepressant that acts primarily as a serotonin antagonist and reuptake inhibitor. Trz, a triazolopyridine derivative, exhibits a wide range of pharmacological effects, including antidepressant, anxiolytic, and sedative-hypnotic properties. A thorough investigation of Trz's electrochemical behavior was performed, with cyclic voltammetry revealing that the modified electrode significantly enhanced the electrocatalytic activity for Trz oxidation. The sensor demonstrated a linear dynamic range of 0.1–60.0 μM and a detection limit of 0.02 μM for Trz in various samples. Additionally, the developed electrode was effective in detecting Trz in biological samples.