{"title":"A Computational Approach to Investigate the Structural Behavior of Bone Scaffold-Implanted Proximal Femur in Routine Clinical Resolution","authors":"Jun Won Choi, Jung Jin Kim","doi":"10.1002/cnm.70072","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Bone scaffolds are artificial structures used to repair or reconstruct damaged bone tissue and restore its function. Various scaffold materials and structures have been studied, but few have assessed their behavior within anatomical geometries using 2D clinical CT data. Therefore, this study employed a computational approach to analyze the structural behavior of bone scaffolds composed of different materials and porous structures when implanted into a 2D model of the proximal femur derived from clinical-resolution CT images. In addition, this study investigated the relationship between the apparent elastic modulus of bone scaffolds and that of the surrounding bone. The results demonstrated that selecting appropriate materials and porous structures is essential for designing scaffolds with AEM values similar to those of native bone. Scaffolds with matching AEM effectively transferred and supported external loads, whereas those designed solely for high stiffness were less effective in load transmission. Notably, in the femoral head, the square and circular scaffolds made with NBM showed the smallest AEM differences from native bone: 0.93% and 8.27%, respectively. In the femoral neck, circular and triangular scaffolds made with PLDLLA/TCP exhibited the smallest differences of 39.38% and 11.00%. In the intertrochanter, honeycomb and triangular scaffolds made with NBM showed the smallest deviations: 24.51% and 33.00%, respectively. Among all combinations, the square-type scaffold with NBM also generated the highest internal strain energy in the femoral head (9.163 μJ), whereas the triangle scaffold with Bioglass/PLGA exhibited the lowest (0.091 μJ). These findings underscore the importance of tailoring scaffold stiffness to specific anatomical sites to optimize mechanical stimulation and promote bone regeneration.</p>\n </div>","PeriodicalId":50349,"journal":{"name":"International Journal for Numerical Methods in Biomedical Engineering","volume":"41 7","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal for Numerical Methods in Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cnm.70072","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Bone scaffolds are artificial structures used to repair or reconstruct damaged bone tissue and restore its function. Various scaffold materials and structures have been studied, but few have assessed their behavior within anatomical geometries using 2D clinical CT data. Therefore, this study employed a computational approach to analyze the structural behavior of bone scaffolds composed of different materials and porous structures when implanted into a 2D model of the proximal femur derived from clinical-resolution CT images. In addition, this study investigated the relationship between the apparent elastic modulus of bone scaffolds and that of the surrounding bone. The results demonstrated that selecting appropriate materials and porous structures is essential for designing scaffolds with AEM values similar to those of native bone. Scaffolds with matching AEM effectively transferred and supported external loads, whereas those designed solely for high stiffness were less effective in load transmission. Notably, in the femoral head, the square and circular scaffolds made with NBM showed the smallest AEM differences from native bone: 0.93% and 8.27%, respectively. In the femoral neck, circular and triangular scaffolds made with PLDLLA/TCP exhibited the smallest differences of 39.38% and 11.00%. In the intertrochanter, honeycomb and triangular scaffolds made with NBM showed the smallest deviations: 24.51% and 33.00%, respectively. Among all combinations, the square-type scaffold with NBM also generated the highest internal strain energy in the femoral head (9.163 μJ), whereas the triangle scaffold with Bioglass/PLGA exhibited the lowest (0.091 μJ). These findings underscore the importance of tailoring scaffold stiffness to specific anatomical sites to optimize mechanical stimulation and promote bone regeneration.
期刊介绍:
All differential equation based models for biomedical applications and their novel solutions (using either established numerical methods such as finite difference, finite element and finite volume methods or new numerical methods) are within the scope of this journal. Manuscripts with experimental and analytical themes are also welcome if a component of the paper deals with numerical methods. Special cases that may not involve differential equations such as image processing, meshing and artificial intelligence are within the scope. Any research that is broadly linked to the wellbeing of the human body, either directly or indirectly, is also within the scope of this journal.