A Computational Approach to Investigate the Structural Behavior of Bone Scaffold-Implanted Proximal Femur in Routine Clinical Resolution

IF 2.2 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Jun Won Choi, Jung Jin Kim
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Abstract

Bone scaffolds are artificial structures used to repair or reconstruct damaged bone tissue and restore its function. Various scaffold materials and structures have been studied, but few have assessed their behavior within anatomical geometries using 2D clinical CT data. Therefore, this study employed a computational approach to analyze the structural behavior of bone scaffolds composed of different materials and porous structures when implanted into a 2D model of the proximal femur derived from clinical-resolution CT images. In addition, this study investigated the relationship between the apparent elastic modulus of bone scaffolds and that of the surrounding bone. The results demonstrated that selecting appropriate materials and porous structures is essential for designing scaffolds with AEM values similar to those of native bone. Scaffolds with matching AEM effectively transferred and supported external loads, whereas those designed solely for high stiffness were less effective in load transmission. Notably, in the femoral head, the square and circular scaffolds made with NBM showed the smallest AEM differences from native bone: 0.93% and 8.27%, respectively. In the femoral neck, circular and triangular scaffolds made with PLDLLA/TCP exhibited the smallest differences of 39.38% and 11.00%. In the intertrochanter, honeycomb and triangular scaffolds made with NBM showed the smallest deviations: 24.51% and 33.00%, respectively. Among all combinations, the square-type scaffold with NBM also generated the highest internal strain energy in the femoral head (9.163 μJ), whereas the triangle scaffold with Bioglass/PLGA exhibited the lowest (0.091 μJ). These findings underscore the importance of tailoring scaffold stiffness to specific anatomical sites to optimize mechanical stimulation and promote bone regeneration.

Abstract Image

在常规临床分辨率下研究骨支架植入股骨近端结构行为的计算方法
骨支架是用于修复或重建受损骨组织并恢复其功能的人工结构。已经研究了各种支架材料和结构,但很少有人使用二维临床CT数据评估其在解剖几何中的行为。因此,本研究采用计算方法分析由不同材料和多孔结构组成的骨支架植入临床分辨率CT图像衍生的股骨近端二维模型时的结构行为。此外,本研究还研究了骨支架的表观弹性模量与周围骨的表观弹性模量的关系。结果表明,选择合适的材料和多孔结构是设计AEM值与天然骨相似的支架的关键。与AEM匹配的支架可以有效地传递和支撑外部载荷,而单纯为高刚度设计的支架传递载荷的效果较差。值得注意的是,在股骨头中,用NBM制成的方形和圆形支架与天然骨的AEM差异最小,分别为0.93%和8.27%。在股骨颈,pldla /TCP制成的圆形和三角形支架的差异最小,分别为39.38%和11.00%。在粗隆间,蜂窝状支架和三角形支架的偏差最小,分别为24.51%和33.00%。在所有组合中,含有NBM的方形支架在股骨头处产生的内部应变能最高(9.163 μJ),而含有生物玻璃/PLGA的三角形支架在股骨头处产生的内部应变能最低(0.091 μJ)。这些发现强调了根据特定解剖部位调整支架刚度以优化机械刺激和促进骨再生的重要性。
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来源期刊
International Journal for Numerical Methods in Biomedical Engineering
International Journal for Numerical Methods in Biomedical Engineering ENGINEERING, BIOMEDICAL-MATHEMATICAL & COMPUTATIONAL BIOLOGY
CiteScore
4.50
自引率
9.50%
发文量
103
审稿时长
3 months
期刊介绍: All differential equation based models for biomedical applications and their novel solutions (using either established numerical methods such as finite difference, finite element and finite volume methods or new numerical methods) are within the scope of this journal. Manuscripts with experimental and analytical themes are also welcome if a component of the paper deals with numerical methods. Special cases that may not involve differential equations such as image processing, meshing and artificial intelligence are within the scope. Any research that is broadly linked to the wellbeing of the human body, either directly or indirectly, is also within the scope of this journal.
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