Factors associated with anxiety and depression symptoms among women with endometriosis: A cross-sectional study within the ComPaRe-Endometriosis cohort

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-07-19 DOI:10.1016/j.jpsychores.2025.112329

Zélia Breton , Solène Gouesbet , Hélène Amazouz , Hélèna Schoefs , Viet-Thi Tran , Bruno Falissard , Emmanuelle Corruble , Marina Kvaskoff

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引用次数: 0

Abstract

Context and objectives

Women with endometriosis report higher anxiety and depression levels compared with the general population. While numerous studies focused on chronic pain, few have investigated broader potential correlates of mental well-being in patients with endometriosis. This cross-sectional study aimed to highlight the factors associated with higher anxiety and depression symptoms in women with endometriosis.

Methods

We conducted a cross-sectional analysis among 2394 participants of the ComPaRe-Endometriosis e-cohort. Symptoms of anxiety and depression were assessed via GAD-7 and PHQ-9 scales at baseline. We used polytomous logistic regression modeling to explore the factors associated with anxiety and depression symptoms severity after adjustment for age, body mass index (BMI), number of comorbidities, diagnostic delay, and age at first symptoms.

Results

Overall, 32 % and 45 % of participants had moderate-to-severe anxiety and depression symptoms respectively. Factors positively associated with higher anxiety/depression symptom severity included lower education, poor sleep quality, reduced quality of life, severity of pelvic/abdominal pain, number of comorbidities, higher BMI, number of medical consultations to diagnosis, and use of complementary medicine. In contrast, older age, a financial situation perceived as comfortable, lack of pain treatment or less frequent transvaginal ultrasound follow-ups were associated with lower anxiety and depression symptoms.

Conclusion

This study identified several sociodemographic and medical factors associated with higher severity of anxiety and depression symptoms in women with endometriosis. If confirmed in future studies, these results could guide preventive strategies, enhance healthcare provider training, and optimize treatments for improved patient-centered care.

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子宫内膜异位症女性焦虑和抑郁症状相关因素：一项比较子宫内膜异位症队列的横断面研究

背景和目的与一般人群相比，患有子宫内膜异位症的女性有更高的焦虑和抑郁水平。虽然许多研究都集中在慢性疼痛上，但很少有人研究子宫内膜异位症患者心理健康的潜在关联。本横断面研究旨在强调与子宫内膜异位症患者焦虑和抑郁症状加重相关的因素。方法我们对2394名比较子宫内膜异位症e队列的参与者进行了横断面分析。在基线时通过GAD-7和PHQ-9量表评估焦虑和抑郁症状。在调整年龄、体重指数（BMI）、合并症数量、诊断延迟和首次出现症状的年龄后，我们使用多元逻辑回归模型来探讨与焦虑和抑郁症状严重程度相关的因素。结果总体而言，32%和45%的参与者分别有中度至重度焦虑和抑郁症状。与焦虑/抑郁症状严重程度呈正相关的因素包括：受教育程度较低、睡眠质量差、生活质量下降、骨盆/腹部疼痛严重程度、合并症数量、较高的BMI、就诊次数以及辅助药物的使用。相比之下，年龄较大、经济状况舒适、缺乏疼痛治疗或较少的阴道超声随访与较低的焦虑和抑郁症状有关。结论：本研究确定了与子宫内膜异位症患者焦虑和抑郁症状加重程度相关的几个社会人口统计学和医学因素。如果在未来的研究中得到证实，这些结果可以指导预防策略，加强医疗保健提供者培训，并优化治疗，以改善以患者为中心的护理。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.