Controlled recrystallization of high-purity, large-particle sodium bicarbonate crystals via CO2-assisted thermal stabilization

IF 2 4区材料科学 Q3 CRYSTALLOGRAPHY

Journal of Crystal Growth Pub Date : 2025-07-21 DOI:10.1016/j.jcrysgro.2025.128307

Haojie Jiang , Shuai Wang , Yixin Tang , Feng Ma , Lei Wu , Guoyong Wang , Wu Yin , Yiqiao Hu , Hong Dong

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引用次数: 0

Abstract

Sodium bicarbonate (NaHCO₃) is widely used in medicine, environmental protection, and industrial maintenance, yet the production of high-purity, uniformly sized, large-particle crystals remains challenging. Conventional methods, such as recrystallizing industrial-grade NaHCO₃ or carbonating soda ash, often fail to meet pharmaceutical-grade requirements efficiently. In this study, we developed a simplified, cost-effective recrystallization strategy by optimizing dissolution temperature, CO₂ pressure, stirring speed, and crystallization time. Dissolving NaHCO₃ at 75 ℃ under 0.2 MPa CO₂ minimized thermal decomposition and stabilized the supersaturated solution, while crystallization at 45 ℃ followed by a 4‑hour static growth phase produced large (300–400 μm), uniform crystals with enhanced purity and reproducibility. Four repeated crystallization cycles confirmed the high stability and yield of the process. This work offers a practical approach for reliably producing pharmaceutical-grade NaHCO₃ crystals and provides a valuable reference for advancing industrial crystallization technology.

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利用二氧化碳辅助热稳定技术控制高纯度大颗粒碳酸氢钠晶体的再结晶

碳酸氢钠（NaHCO3）广泛应用于医药、环保和工业维护，但生产高纯度、均匀尺寸的大颗粒晶体仍然具有挑战性。传统的方法，如重结晶工业级NaHCO3或碳酸化纯碱，往往不能有效地满足制药级的要求。在这项研究中，我们通过优化溶解温度、CO2压力、搅拌速度和结晶时间，开发了一种简单、经济的再结晶策略。在75℃，0.2 MPa CO2下溶解NaHCO3，使热分解最小化，并稳定了过饱和溶液，而在45℃下结晶，然后静生长期4小时，可以得到大（300-400 μm），均匀的晶体，提高了纯度和再现性。四次重复结晶循环证实了该工艺的高稳定性和收率。本研究为可靠生产医药级NaHCO3晶体提供了一种实用的方法，并为推进工业结晶技术提供了有价值的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Crystal Growth 化学-晶体学

CiteScore

3.60

自引率

11.10%

发文量

373

审稿时长

65 days

期刊介绍： The journal offers a common reference and publication source for workers engaged in research on the experimental and theoretical aspects of crystal growth and its applications, e.g. in devices. Experimental and theoretical contributions are published in the following fields: theory of nucleation and growth, molecular kinetics and transport phenomena, crystallization in viscous media such as polymers and glasses; crystal growth of metals, minerals, semiconductors, superconductors, magnetics, inorganic, organic and biological substances in bulk or as thin films; molecular beam epitaxy, chemical vapor deposition, growth of III-V and II-VI and other semiconductors; characterization of single crystals by physical and chemical methods; apparatus, instrumentation and techniques for crystal growth, and purification methods; multilayer heterostructures and their characterisation with an emphasis on crystal growth and epitaxial aspects of electronic materials. A special feature of the journal is the periodic inclusion of proceedings of symposia and conferences on relevant aspects of crystal growth.