{"title":"The role of matrix metalloproteinases in the modulation of aqueous humor in glaucoma patients.","authors":"Cerbulescu Teodor, Barac Ileana Ramona, Boruga Ovidiu, Sălăvăţ Mădălina Casiana, Leuştean Laurenţiu, Duncă Ştefan Daciana, Calancea Andrei, Barac Andreea Diana","doi":"10.22336/rjo.2025.33","DOIUrl":null,"url":null,"abstract":"<p><p>Matrix metalloproteinases are crucial proteolytic enzymes involved in the degradation and remodeling of the extracellular matrix within the ocular structures. Their expression and activity significantly influence aqueous humor dynamics and intraocular pressure in patients with glaucoma. Elevated intraocular pressure, a significant risk factor for glaucoma, is often associated with disturbed aqueous humor outflow. This review summarizes current findings on the role of matrix metalloproteinases in modulating aqueous humor and their potential as therapeutic targets in the treatment of glaucoma.</p>","PeriodicalId":94355,"journal":{"name":"Romanian journal of ophthalmology","volume":"69 2","pages":"208-211"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277996/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian journal of ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22336/rjo.2025.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Matrix metalloproteinases are crucial proteolytic enzymes involved in the degradation and remodeling of the extracellular matrix within the ocular structures. Their expression and activity significantly influence aqueous humor dynamics and intraocular pressure in patients with glaucoma. Elevated intraocular pressure, a significant risk factor for glaucoma, is often associated with disturbed aqueous humor outflow. This review summarizes current findings on the role of matrix metalloproteinases in modulating aqueous humor and their potential as therapeutic targets in the treatment of glaucoma.
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