Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in pediatrics.

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica Pub Date : 2025-07-15 DOI:10.54847/cp.2025.03.15

D Del Gordo Caballero, J Mancera Morales, C E Villamil Giraldo, S Ruiz Gutiérrez, A F Siabatto Cleves, J P Luengas Monroy

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Abstract

Introduction: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has a low malignancy potential. First acknowledged by the WHO in 2017, this tumor is rare in the pediatric population, with less than 25 cases reported. Accurate diagnosis is key to avoid overtreatment and complications.

Clinical observation: Two cases of adolescents with solid thyroid nodules assessed by fine-needle aspiration biopsy are presented. Hemithyroidectomy was decided upon. Both surgical specimens were reported as NIFTP. Both cases were presented before a cross-disciplinary board, and since malignancy potential was low, treatment was regarded as completed.

Discussion: NIFTP identification is key to avoid unnecessary treatments such as total thyroidectomy or iodine therapy, which may bring about serious consequences in children. A high level of diagnostic suspicion and a cross-disciplinary approach are required to optimize management and clinical results in these patients.

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具有乳头状核特征的儿科非侵袭性滤泡性甲状腺肿瘤。

具有乳头状核特征的非侵袭性甲状腺滤泡性肿瘤（NIFTP）具有低恶性潜能。世界卫生组织于2017年首次承认，这种肿瘤在儿科人群中很罕见，报告的病例不到25例。准确诊断是避免过度治疗和并发症的关键。临床观察：报告两例青少年实性甲状腺结节的细针穿刺活检。决定切除半甲状腺。两例手术标本均为NIFTP。这两个病例都被提交给一个跨学科委员会，由于恶性肿瘤的可能性很低，治疗被认为是完成的。讨论：NIFTP的识别是避免不必要的治疗的关键，如全甲状腺切除术或碘治疗，这可能会给儿童带来严重的后果。需要高度的诊断怀疑和跨学科的方法来优化这些患者的管理和临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica

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