Transfer RNA-derived small RNAs in liver disease.

IF 4.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Qin-Yuan Huang, Zi-Yan Zhou, Yi-Le Zhang, Yang Zhou, Shi-Wei Duan, Jing-Yin Dong
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引用次数: 0

Abstract

Transfer RNA-derived small RNA (tsRNA) is a novel class of small non-coding RNAs (sncRNAs) that are generated through precise enzymatic cleavage of mature tRNAs or their precursor molecules. These tsRNAs play a pivotal role in regulating cellular processes such as protein synthesis, translation, and gene expression networks. This review offers a comprehensive overview of the functional characteristics of 24 tsRNAs, highlighting significant changes in their expression profiles across various liver diseases. Notably, 13 tsRNAs are upregulated, while 4 are downregulated in liver diseases compared to healthy controls, providing new insights into their biological roles. A major focus of this review is the latest research on the involvement of tsRNAs in a range of liver diseases, including hepatitis B and C, alcoholic liver disease, metabolic dysfunction-associated steatotic liver disease (MASLD, or non-alcoholic fatty liver disease, NAFLD), and hepatocellular carcinoma (HCC). This review explored how altered expression of tsRNAs in these conditions contributes to disease progression, along with the underlying regulatory mechanisms. Beyond their molecular roles, this review also examined the potential of tsRNAs as diagnostic and prognostic biomarkers for liver diseases. Due to their unique biological characteristics and functional versatility, tsRNAs hold promise as therapeutic targets in precision medicine. By highlighting their potential for developing more effective, targeted therapies, this review paves the way for future clinical applications of tsRNAs in liver disease treatment.

转移rna衍生的小rna在肝脏疾病中的作用。
转移RNA衍生小RNA (Transfer RNA-derived small RNA, tsRNA)是一类新型的非编码小RNA (sncRNAs),它是通过对成熟tRNAs或其前体分子进行精确的酶切而产生的。这些tsRNAs在调节蛋白质合成、翻译和基因表达网络等细胞过程中起着关键作用。本文综述了24种tsRNAs的功能特征,强调了它们在各种肝脏疾病中的表达谱的显著变化。值得注意的是,与健康对照相比,13种tsRNAs在肝脏疾病中上调,而4种tsRNAs下调,这为其生物学作用提供了新的见解。本综述的主要焦点是tsRNAs在一系列肝脏疾病中的最新研究,包括乙型和丙型肝炎、酒精性肝病、代谢功能障碍相关的脂肪变性肝病(MASLD,或非酒精性脂肪性肝病,NAFLD)和肝细胞癌(HCC)。这篇综述探讨了这些疾病中tsRNAs表达的改变是如何促进疾病进展的,以及潜在的调节机制。除了它们的分子作用外,本综述还研究了tsRNAs作为肝脏疾病诊断和预后生物标志物的潜力。由于其独特的生物学特性和功能的多功能性,tsRNAs有望成为精准医学的治疗靶点。通过强调它们在开发更有效的靶向治疗方面的潜力,本综述为tsRNAs在肝脏疾病治疗中的未来临床应用铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.40
自引率
6.10%
发文量
152
审稿时长
3.0 months
期刊介绍: Hepatobiliary & Pancreatic Diseases International (HBPD INT) (ISSN 1499-3872 / CN 33-1391/R) a bimonthly journal published by First Affiliated Hospital, Zhejiang University School of Medicine, China. It publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases. Papers cover the medical, surgical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas under the headings Liver, Biliary, Pancreas, Transplantation, Research, Special Reports, Editorials, Review Articles, Brief Communications, Clinical Summary, Clinical Images and Case Reports. It also deals with the basic sciences and experimental work. The journal is abstracted and indexed in SCI-E, IM/MEDLINE, EMBASE/EM, CA, Scopus, ScienceDirect, etc.
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