Interactive interdisciplinary pain research in adolescent and young adult females: a pilot investigation of brain, physiological, and emotional functioning following orthopedic surgery.

IF 2.1 3区心理学 Q2 PSYCHOLOGY, DEVELOPMENTAL

Journal of Pediatric Psychology Pub Date : 2025-07-22 DOI:10.1093/jpepsy/jsaf041

Ziyan Wu, Margaret Moreland, Maya L Jotwani, Melissa A Christino, David Borsook, Christine B Sieberg

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引用次数: 0

Abstract

Objective: In this pilot investigation, we aimed to explore the neurological and biobehavioral mechanisms underlying pain outcomes in adolescent and young adult (AYA) females following orthopedic surgery, an area largely unexplored.

Methods: Functional near-infrared spectroscopy was used to investigate brain responses in the primary sensory cortex (sensory pain processing) and the prefrontal regions (emotional processing) in 24 AYA females who underwent orthopedic surgery within the previous 2 years compared to 20 group-matched controls without a surgical or chronic pain history. A battery of self-reported pain-related and emotional functioning measures (PROMIS; pain catastrophizing) were also administered. Cortical activations and functional connectivity (FC), involving the prefrontal (PFC) and somatosensory cortices (SMC), were assessed during resting state and a descending pain modulation task (conditioned pain modulation).

Results: In the control group, PFC-SMC FC in response to pain was significantly linked to anxiety, whereas this correlation was absent in the post-surgical cohort.

Conclusion: These results highlight distinct altered responses in sensory and emotional brain functioning in AYA females following orthopedic surgery. We suggest that such changes may be related to the involvement of the PFC-SMC communication in the maintenance of chronic pain.

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青少年和年轻成年女性的互动跨学科疼痛研究：骨科手术后脑、生理和情绪功能的初步调查。

目的：在这项试点研究中，我们旨在探索青少年和年轻成人（AYA）女性骨科手术后疼痛结局的神经学和生物行为机制，这是一个很大程度上尚未探索的领域。方法：使用功能性近红外光谱研究了24名在过去2年内接受骨科手术的AYA女性的初级感觉皮层（感觉疼痛处理）和前额叶区域（情绪处理）的大脑反应，并与20名没有手术或慢性疼痛史的对照组进行了比较。一系列自我报告的疼痛相关和情绪功能测量(PROMIS；疼痛灾难化)也被给予。在静息状态和下行疼痛调节任务（条条性疼痛调节）期间，对涉及前额叶（PFC）和体感皮质（SMC）的皮质激活和功能连接（FC）进行了评估。结果：在对照组中，PFC-SMC FC对疼痛的反应与焦虑显著相关，而这种相关性在术后队列中不存在。结论：这些结果突出了AYA女性在骨科手术后感觉和情绪脑功能的明显改变。我们认为这种变化可能与PFC-SMC通讯参与慢性疼痛的维持有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Psychology PSYCHOLOGY, DEVELOPMENTAL-

CiteScore

6.00

自引率

11.10%

发文量

期刊介绍： The Journal of Pediatric Psychology is the official journal of the Society of Pediatric Psychology, Division 54 of the American Psychological Association. The Journal of Pediatric Psychology publishes articles related to theory, research, and professional practice in pediatric psychology. Pediatric psychology is an integrated field of science and practice in which the principles of psychology are applied within the context of pediatric health. The field aims to promote the health and development of children, adolescents, and their families through use of evidence-based methods.