Comparison of fentanyl and alfentanil in combination with atropine for premedication of dogs undergoing radiotherapy

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia Pub Date : 2025-06-13 DOI:10.1016/j.vaa.2025.06.004

Giovanni Franchino, Adam Shuttleworth, Pietro Loddo, Chiara Adami

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引用次数: 0

Abstract

Objective

To evaluate the effects of two opioid-based premedication protocols on propofol requirement, time to recovery and occurrence of post-anaesthetic vocalization, paddling, nystagmus and dysphoria in dogs anaesthetized for radiotherapy.

Study design

Blinded, randomized, crossover clinical study.

Animals

A total of 22 client-owned dogs, each serving as their own control.

Methods

Dogs were randomly assigned to one of two intravenous premedication protocols on their first radiotherapy session, and the other on their second session. Premedication consisted of atropine (10 μg kg⁻¹) mixed with equipotent doses of either alfentanil (10 μg kg⁻¹, group AA) or fentanyl (2.5 μg kg⁻¹, group FA), followed by propofol induction and maintenance with sevoflurane in oxygen. Cardiorespiratory variables and observation of dysphoria and nystagmus were recorded after premedication and during recovery. Time elapsed from discontinuation of sevoflurane to tracheal extubation, sternal position and walking were also recorded (minutes).

Results

The proportion of dogs showing dysphoria and nystagmus was not different between treatments at any time point. With both treatments, heart rate (mean ± standard deviation) decreased after premedication (82 ± 27 and 93 ± 27 beats minute⁻¹ in groups AA and FA, respectively) compared with baseline (117 ± 23 and 112 ± 26 beats minute⁻¹ in groups AA and FA, respectively; p < 0.001). Propofol dose did not differ between treatments (3.8 ± 1.7 and 4.3 ± 1.3 mg kg⁻¹ in groups AA and FA, respectively). Time to extubation was shorter with treatment AA (5.3 ± 2.1 minutes) compared with treatment FA (6.2 ± 2.3 minutes; p = 0.049), while time to sternal recumbency and walking did not differ between treatments.

Conclusions and clinical relevance

Since the two protocols produced comparable clinical effects and were both found suitable for dogs undergoing repeated radiotherapy, fentanyl is recommended over alfentanil in countries where it is licensed.

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芬太尼与阿芬太尼联合阿托品对犬放射治疗前用药的比较。

目的：评价两种基于阿片类药物的预用药方案对麻醉放疗犬异丙酚需用量、恢复时间及麻醉后发声、拍打、眼球震颤和烦躁的发生情况的影响。研究设计：盲法、随机、交叉临床研究。动物：共有22只客户拥有的狗，每只都是他们自己的对照。方法：狗被随机分配到两种静脉注射前治疗方案中的一种，在第一次放疗期间，另一种在第二次放疗期间。用药前：阿托品（10 μg kg-1）与等剂量的阿芬太尼（10 μg kg-1， AA组）或芬太尼（2.5 μg kg-1， FA组）混合，然后异丙酚诱导和七氟醚氧维持。记录用药前及康复期间的心肺指标及烦躁不安、眼球震颤的观察。同时记录从停用七氟醚到拔管、胸骨位和行走的时间（分钟）。结果：不同治疗时间点出现烦躁不安和眼球震颤的比例无显著差异。两组患者用药前心率（平均±标准差）均低于基线（AA组为117±23，FA组为112±26，AA组为82±27，FA组为93±27，min -1）；P < 0.001)。不同处理间异丙酚剂量差异无统计学意义（AA组3.8±1.7 mg kg-1， FA组4.3±1.3 mg kg-1）。AA组拔管时间（5.3±2.1分钟）短于FA组（6.2±2.3分钟）；P = 0.049)，而到胸骨平躺和行走的时间在两组间无差异。结论和临床相关性：由于两种方案的临床效果相当，并且都适用于接受反复放疗的狗，因此在芬太尼许可的国家，芬太尼比阿芬太尼更被推荐使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary anaesthesia and analgesia 农林科学-兽医学

CiteScore

3.10

自引率

17.60%

发文量

审稿时长

97 days

期刊介绍： Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome: the basic sciences; pathophysiology of disease as it relates to anaesthetic management equipment intensive care chemical restraint of animals including laboratory animals, wildlife and exotic animals welfare issues associated with pain and distress education in veterinary anaesthesia and analgesia. Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.