Effects of a Single Session 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double-Blind RCT.

IF 2.8 2区心理学 Q2 NEUROSCIENCES

Psychophysiology Pub Date : 2025-07-01 DOI:10.1111/psyp.70112

Shapour Jaberzadeh, Mona Malekahmad, Renming Liu, Maryam Zoghi

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Abstract

The effects of 400 Hz anodal and cathodal transcranial pulsed current stimulation of the primary motor cortex (400 Hz a-tPCS_M1, 400 Hz c-tPCS_M1) on corticospinal excitability (CSE) and corticocortical excitability (CCE) and hand dexterity remain underexplored. This study examined the effects of a single session of 400 Hz a-tPCS_M1, 400 Hz c-tPCS_M1, and sham stimulation on CSE, CCE, and hand dexterity, providing insights for potential clinical applications in motor deficits. In this double-blinded, randomized, counterbalanced crossover trial, 26 healthy young adults completed three experimental sessions: 400 Hz a-tPCS_M1, 400 Hz c-tPCS_M1, and sham stimulation, spaced 48 h apart. Transcranial magnetic stimulation assessed CSE and CCE, while the Purdue Pegboard Test (PPT) evaluated hand dexterity. The results showed polarity-specific effects. A single session of 400 Hz a-tPCS_M1 significantly increased CSE and improved hand dexterity, evidenced by faster PPT completion times (p < 0.05). Conversely, 400 Hz c-tPCS_M1 reduced CSE but did not influence PPT performance (p > 0.05). Sham stimulation showed no significant changes. These findings suggest that 400 Hz a-tPCS_M1 enhances motor excitability and dexterity, while 400 Hz c-tPCS_M1 selectively reduces CSE. This study lays a foundation for exploring high-frequency tPCS in clinical motor rehabilitation.

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单次400hz经颅脉冲电流刺激对皮质脊髓和皮质皮质兴奋性及手灵巧性的影响：一项双盲随机对照试验。

400 Hz经颅脉冲电流刺激初级运动皮层（400 Hz a-tPCSM1, 400 Hz c-tPCSM1）对皮质脊髓兴奋性（CSE）、皮质皮质兴奋性（CCE）和手灵巧性的影响尚不清楚。本研究考察了单次400 Hz a- tpcsm1、400 Hz c-tPCSM1和假刺激对CSE、CCE和手灵巧的影响，为运动缺陷的潜在临床应用提供了见解。在这项双盲、随机、平衡交叉试验中，26名健康年轻人完成了三个实验阶段：400 Hz a-tPCSM1、400 Hz c-tPCSM1和假刺激，间隔48小时。经颅磁刺激评估CSE和CCE，而普渡钉板测试（PPT）评估手灵巧性。结果显示极性特异性效应。单次400 Hz A - tpcsm1显著提高了CSE和手部灵巧性，证明了更快的PPT完成时间(p M1降低了CSE，但不影响PPT表现（p > 0.05）。假性刺激无明显变化。这些结果表明，400 Hz a-tPCSM1增强了运动兴奋性和灵巧性，而400 Hz c-tPCSM1选择性地降低了CSE。本研究为探索高频tPCS在临床运动康复中的应用奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychophysiology 医学-神经科学

CiteScore

6.80

自引率

8.10%

发文量

225

审稿时长

2 months

期刊介绍： Founded in 1964, Psychophysiology is the most established journal in the world specifically dedicated to the dissemination of psychophysiological science. The journal continues to play a key role in advancing human neuroscience in its many forms and methodologies (including central and peripheral measures), covering research on the interrelationships between the physiological and psychological aspects of brain and behavior. Typically, studies published in Psychophysiology include psychological independent variables and noninvasive physiological dependent variables (hemodynamic, optical, and electromagnetic brain imaging and/or peripheral measures such as respiratory sinus arrhythmia, electromyography, pupillography, and many others). The majority of studies published in the journal involve human participants, but work using animal models of such phenomena is occasionally published. Psychophysiology welcomes submissions on new theoretical, empirical, and methodological advances in: cognitive, affective, clinical and social neuroscience, psychopathology and psychiatry, health science and behavioral medicine, and biomedical engineering. The journal publishes theoretical papers, evaluative reviews of literature, empirical papers, and methodological papers, with submissions welcome from scientists in any fields mentioned above.