Capsaicin-assessed cough reflex in asthma patients.

IF 1.9 4区 医学 Q3 PHYSIOLOGY
Physiological research Pub Date : 2025-07-23
M Neuschlova, P Kunc, R Pecova
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Abstract

The cough reflex is a primary defensive mechanism for airway protection. Cough disorders are characterized by a change in the threshold for initiating the cough reflex. Various afferent inputs influence the onset and sensitivity of the cough reflex. The study aimed to determine and compare the cough reflex sensitivity between adults with asthma and healthy adults with no history of allergic, respiratory, cardiovascular, gastrointestinal, or endocrine diseases, using European Respiratory Society guidelines on the assessment of cough. We created a group of 52 healthy volunteers (mean age 33.8 years) to serve as a control group for future research into the cough reflex in defined patient groups in upcoming clinical-physiological studies. We found that in the group of healthy volunteers, the threshold concentration of capsaicin required to elicit at least two coughs (C2) was 8.46 micromol/l, while the threshold concentration for inducing at least five coughs (C5) was 26.62 micromol/l. We then compared the reactivity of afferent nerve endings in the airways of healthy adults and adults with asthma by evaluating the differences in the concentrations of capsaicin that elicited C2 and C5 in these two groups. In a group of 19 asthmatic adults (mean age 33 years), the threshold concentration of capsaicin required to induce C2 was 2.03 micromol/l, while the threshold concentration for C5 was 3.02 micromol/l. We demonstrated a significant increase in cough reflex sensitivity in adults with asthma, expressed as the C2 capsaicin concentration (P<0.01) and the C5 concentration (P<0.001). Key words Cough " Cough reflex sensitivity " Capsaicin " Asthma.

辣椒素评估哮喘患者咳嗽反射。
咳嗽反射是气道保护的主要防御机制。咳嗽障碍的特征是启动咳嗽反射的阈值发生变化。不同的传入输入影响咳嗽反射的发生和敏感性。该研究旨在确定和比较哮喘成人和无过敏、呼吸、心血管、胃肠道或内分泌疾病史的健康成人的咳嗽反射敏感性,采用欧洲呼吸学会咳嗽评估指南。我们创建了一组52名健康志愿者(平均年龄33.8岁)作为对照组,为即将进行的临床生理学研究中确定患者组的咳嗽反射进行进一步研究。我们发现,在健康志愿者组中,引起至少两次咳嗽(C2)所需的辣椒素阈浓度为8.46微mol/l,而引起至少五次咳嗽(C5)所需的辣椒素阈浓度为26.62微mol/l。然后,我们通过评估两组中引起C2和C5的辣椒素浓度的差异,比较了健康成人和哮喘成人气道传入神经末梢的反应性。在19例哮喘成人(平均年龄33岁)中,诱发C2所需的辣椒素阈浓度为2.03微mol/l,而诱发C5所需的辣椒素阈浓度为3.02微mol/l。我们发现成人哮喘患者咳嗽反射敏感性显著增加,表现为C2辣椒素浓度(P
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来源期刊
Physiological research
Physiological research 医学-生理学
CiteScore
4.00
自引率
4.80%
发文量
108
审稿时长
3 months
期刊介绍: Physiological Research is a peer reviewed Open Access journal that publishes articles on normal and pathological physiology, biochemistry, biophysics, and pharmacology. Authors can submit original, previously unpublished research articles, review articles, rapid or short communications. Instructions for Authors - Respect the instructions carefully when submitting your manuscript. Submitted manuscripts or revised manuscripts that do not follow these Instructions will not be included into the peer-review process. The articles are available in full versions as pdf files beginning with volume 40, 1991. The journal publishes the online Ahead of Print /Pre-Press version of the articles that are searchable in Medline and can be cited.
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