Clinical Characteristics and Epidemiology of Cardiovascular Autonomic Neuropathy in Peoples With Long-Standing Diabetes.

IF 2.3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Sook Jung Lee, Chong Hwa Kim, Su Jin Jeong, Jae-Seung Yun, Jong Chul Won, Jae Hyuk Lee, Ie Byung Park, Chang Won Lee, Hyuk-Sang Kwon, Tae Sun Park
{"title":"Clinical Characteristics and Epidemiology of Cardiovascular Autonomic Neuropathy in Peoples With Long-Standing Diabetes.","authors":"Sook Jung Lee, Chong Hwa Kim, Su Jin Jeong, Jae-Seung Yun, Jong Chul Won, Jae Hyuk Lee, Ie Byung Park, Chang Won Lee, Hyuk-Sang Kwon, Tae Sun Park","doi":"10.3346/jkms.2025.40.e154","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular autonomic neuropathy (CAN) is a frequently underdiagnosed complication of diabetes mellitus that contributes to increased mortality and morbidity rates. This multicenter study investigated the epidemiology and clinical characteristics of CAN in patients with long-term diabetes.</p><p><strong>Methods: </strong>Retrospective data were collected from 884 individuals with diabetes who were assessed for CAN across eight hospitals in Korea. CAN was diagnosed using electrocardiography and cardiovascular autonomic function tests, including the heart rate-corrected QT interval and Ewing's method. This study evaluated the clinical characteristics, cardiovascular autonomic nerve function test results, and risk factors associated with CAN.</p><p><strong>Results: </strong>Among the 884 patients, 778 (88%) were diagnosed with CAN (DCAN), while 106 (12%) were not (non-DCAN). Individuals with DCAN were older, had a longer duration of diabetes, and had higher creatinine levels. The DCAN group showed decreased time and frequency parameters of heart rate variability (HRV). A multiple logistic regression analysis revealed that a longer diabetes duration, older age, and higher creatinine level were significant risk factors for CAN.</p><p><strong>Conclusion: </strong>CAN was associated with advanced age, a longer duration of diabetes, higher creatinine levels, and lower time and frequency HRV parameters.</p>","PeriodicalId":16249,"journal":{"name":"Journal of Korean Medical Science","volume":"40 28","pages":"e154"},"PeriodicalIF":2.3000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284305/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Korean Medical Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3346/jkms.2025.40.e154","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Cardiovascular autonomic neuropathy (CAN) is a frequently underdiagnosed complication of diabetes mellitus that contributes to increased mortality and morbidity rates. This multicenter study investigated the epidemiology and clinical characteristics of CAN in patients with long-term diabetes.

Methods: Retrospective data were collected from 884 individuals with diabetes who were assessed for CAN across eight hospitals in Korea. CAN was diagnosed using electrocardiography and cardiovascular autonomic function tests, including the heart rate-corrected QT interval and Ewing's method. This study evaluated the clinical characteristics, cardiovascular autonomic nerve function test results, and risk factors associated with CAN.

Results: Among the 884 patients, 778 (88%) were diagnosed with CAN (DCAN), while 106 (12%) were not (non-DCAN). Individuals with DCAN were older, had a longer duration of diabetes, and had higher creatinine levels. The DCAN group showed decreased time and frequency parameters of heart rate variability (HRV). A multiple logistic regression analysis revealed that a longer diabetes duration, older age, and higher creatinine level were significant risk factors for CAN.

Conclusion: CAN was associated with advanced age, a longer duration of diabetes, higher creatinine levels, and lower time and frequency HRV parameters.

Abstract Image

Abstract Image

Abstract Image

长期糖尿病患者心血管自主神经病变的临床特点和流行病学。
背景:心血管自主神经病变(CAN)是糖尿病的一种常见的未被诊断的并发症,它会增加死亡率和发病率。本多中心研究探讨了长期糖尿病患者CAN的流行病学和临床特征。方法:回顾性收集韩国8家医院的884名糖尿病患者的CAN评估数据。CAN的诊断采用心电图和心血管自主功能测试,包括心率校正QT间期和Ewing法。本研究评估了CAN的临床特征、心血管自主神经功能测试结果和相关危险因素。结果:884例患者中,778例(88%)诊断为CAN (DCAN), 106例(12%)未诊断为CAN(非DCAN)。DCAN患者年龄较大,糖尿病病程较长,肌酐水平较高。DCAN组心率变异性(HRV)时间和频率参数降低。多元logistic回归分析显示,糖尿病病程较长、年龄较大、肌酐水平较高是CAN的显著危险因素。结论:CAN与高龄、糖尿病病程较长、肌酐水平较高、HRV时间和频率参数较低有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Korean Medical Science
Journal of Korean Medical Science 医学-医学:内科
CiteScore
7.80
自引率
8.90%
发文量
320
审稿时长
3-6 weeks
期刊介绍: The Journal of Korean Medical Science (JKMS) is an international, peer-reviewed Open Access journal of medicine published weekly in English. The Journal’s publisher is the Korean Academy of Medical Sciences (KAMS), Korean Medical Association (KMA). JKMS aims to publish evidence-based, scientific research articles from various disciplines of the medical sciences. The Journal welcomes articles of general interest to medical researchers especially when they contain original information. Articles on the clinical evaluation of drugs and other therapies, epidemiologic studies of the general population, studies on pathogenic organisms and toxic materials, and the toxicities and adverse effects of therapeutics are welcome.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信