Sex-Specific Associations of Serum Alkaline Phosphatase With Metabolic Syndrome and Its Components: Over 15 Years of Follow-Up Among Iranian Adults.

IF 2.9 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Journal of Clinical Laboratory Analysis Pub Date : 2025-08-01 Epub Date: 2025-07-23 DOI:10.1002/jcla.70075

Parto Hadaegh, Amir Abdi, Mitra Hasheminia, Farzad Hadaegh, Fereidoun Azizi, Maryam Tohidi

{"title":"Sex-Specific Associations of Serum Alkaline Phosphatase With Metabolic Syndrome and Its Components: Over 15 Years of Follow-Up Among Iranian Adults.","authors":"Parto Hadaegh, Amir Abdi, Mitra Hasheminia, Farzad Hadaegh, Fereidoun Azizi, Maryam Tohidi","doi":"10.1002/jcla.70075","DOIUrl":null,"url":null,"abstract":"Background: To investigate the association of serum alkaline phosphatase (ALP) with incident metabolic syndrome (MetS) and its components, as well as the influence of sex on this relationship among Iranian adults.Methods: The multivariable Cox proportional hazards regression models were applied to assess the associations between ALP both as continuous and categorical variables with incident MetS and its components.Results: Among 831 subjects (467 women) with a mean age of 44.51 years, during a median follow-up of 15.6 years, 597 MetS cases (336 women) occurred. Interaction was found between ALP quartiles and sex (p-value = 0.006). Among women, increasing levels of ALP across the second to fourth quartiles were associated with hazard ratios (HRs) of 1.269, 1.491, and 2.092 for MetS, respectively (p for trend < 0.001). Among men, no association was found between ALP and incident MetS. Among women, the second and fourth quartiles of ALP were associated with incident high triglycerides (TG), with HRs of 1.793 and 1.815, respectively. Moreover, a 1-SD increase in ALP conferred a 17.9% higher risk of low high-density lipoprotein cholesterol (HDL-C). Among men, a 1-SD increase in ALP was associated with an HR of 1.222 for incident high waist circumference (WC) (All p-values < 0.05).Conclusion: Sex significantly influenced the impact of serum ALP on the incidence of MetS and its components. In women, ALP was a strong harbinger for incident MetS and its dyslipidemia components. However, among men, the increasing value of ALP was associated with incident central obesity but not MetS.","PeriodicalId":15509,"journal":{"name":"Journal of Clinical Laboratory Analysis","volume":" ","pages":"e70075"},"PeriodicalIF":2.9000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329340/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Laboratory Analysis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jcla.70075","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: To investigate the association of serum alkaline phosphatase (ALP) with incident metabolic syndrome (MetS) and its components, as well as the influence of sex on this relationship among Iranian adults.

Methods: The multivariable Cox proportional hazards regression models were applied to assess the associations between ALP both as continuous and categorical variables with incident MetS and its components.

Results: Among 831 subjects (467 women) with a mean age of 44.51 years, during a median follow-up of 15.6 years, 597 MetS cases (336 women) occurred. Interaction was found between ALP quartiles and sex (p-value = 0.006). Among women, increasing levels of ALP across the second to fourth quartiles were associated with hazard ratios (HRs) of 1.269, 1.491, and 2.092 for MetS, respectively (p for trend < 0.001). Among men, no association was found between ALP and incident MetS. Among women, the second and fourth quartiles of ALP were associated with incident high triglycerides (TG), with HRs of 1.793 and 1.815, respectively. Moreover, a 1-SD increase in ALP conferred a 17.9% higher risk of low high-density lipoprotein cholesterol (HDL-C). Among men, a 1-SD increase in ALP was associated with an HR of 1.222 for incident high waist circumference (WC) (All p-values < 0.05).

Conclusion: Sex significantly influenced the impact of serum ALP on the incidence of MetS and its components. In women, ALP was a strong harbinger for incident MetS and its dyslipidemia components. However, among men, the increasing value of ALP was associated with incident central obesity but not MetS.

Abstract Image

查看原文本刊更多论文

血清碱性磷酸酶与代谢综合征及其成分的性别特异性关联：在伊朗成年人中超过15年的随访

背景：研究伊朗成年人血清碱性磷酸酶（ALP）与代谢综合征（MetS）及其组成的关系，以及性别对这种关系的影响。方法：应用多变量Cox比例风险回归模型评估ALP作为连续变量和分类变量与事件MetS及其组成部分之间的关系。结果：在平均年龄44.51岁的831名受试者（467名女性）中，在15.6年的中位随访期间，发生了597例MetS病例（336名女性）。ALP四分位数与性别之间存在交互作用（p值= 0.006）。在女性中，ALP水平在第二到第四四分位数的增加与met的危险比（hr）分别为1.269、1.491和2.092相关（p为趋势）。结论：性别显著影响血清ALP对MetS及其组成部分的发生率的影响。在女性中，ALP是发生MetS及其血脂异常成分的一个强有力的先兆。然而，在男性中，ALP值的增加与中心性肥胖有关，而与met无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.