Enhancement of the Mayo Clinic HCM Genotype Predictor Score with Addition of Cardiac Magnetic Resonance Imaging.

IF 2.5 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Iuri Ferreira Felix, Vanessa Karlinski Vizentin, Mateo Alzate-Aguirre, Mehrie Patel, Jeffrey B Geske, Phillip Araoz, John R Giudicessi, Steve R Ommen, Adelaide M Arruda-Olson, Michael J Ackerman, J Martijn Bos
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引用次数: 0

Abstract

This study aimed to evaluate the role of cardiac magnetic resonance (CMR) in updating The Mayo Clinic Hypertrophic Cardiomyopathy (HCM) Genotype Predictor Score. We performed an analysis of 175 HCM patients with an echocardiogram, CMR, and genetic test at the Mayo Clinic (2004 to 2018). Yield of a positive genetic test for the original echocardiogram-based score ranged from 38% (-1 point) to 100% (4 or 5 points), with an AUC of 0.659. Late gadolinium enhancement (LGE) presence was a strong predictor of positive genetic test (p = 0.002) and was added to the original score to create the updated version. The yield of positive genetic test for the updated score ranged from 25% (-1 point) to 100% (5 or 6 points) (p < 0.001), with an AUC of 0.724 and significant increase in diagnostic accuracy (p = 0.03). The updated genotype predictor score had improved accuracy when compared to the prior version.

增加心脏磁共振成像对梅奥诊所HCM基因型预测评分的增强。
本研究旨在评估心脏磁共振(CMR)在更新梅奥诊所肥厚性心肌病(HCM)基因型预测评分中的作用。我们对2004年至2018年梅奥诊所175名HCM患者进行了超声心动图、CMR和基因检测分析。原始超声心动图评分的基因检测阳性率为38%(-1分)至100%(4或5分),AUC为0.659。晚期钆增强(LGE)的存在是基因检测阳性的强预测因子(p = 0.002),并被添加到原始评分中以创建更新版本。更新后的评分阳性基因检测率从25%(-1分)到100%(5或6分)不等(p
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来源期刊
Journal of Cardiovascular Translational Research
Journal of Cardiovascular Translational Research CARDIAC & CARDIOVASCULAR SYSTEMS-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.10
自引率
2.90%
发文量
148
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Translational Research (JCTR) is a premier journal in cardiovascular translational research. JCTR is the journal of choice for authors seeking the broadest audience for emerging technologies, therapies and diagnostics, pre-clinical research, and first-in-man clinical trials. JCTR''s intent is to provide a forum for critical evaluation of the novel cardiovascular science, to showcase important and clinically relevant aspects of the new research, as well as to discuss the impediments that may need to be overcome during the translation to patient care.
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