Prediction of central visual field deterioration by sector-wise peripapillary vessel density measurement in eyes with retinitis pigmentosa.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2025-07-22 DOI:10.1007/s10792-025-03677-1

Kazuyoshi Okawa, Yume Iwashita, Tatsuya Inoue, Shohei Kawasaki, Yuna Uechi, Misa Miyazato, Kentaro Nakamura, Ryo Asaoka, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono

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引用次数: 0

Abstract

Purpose: To investigate the relationship between the visual field (VF) deterioration and vessel density (VD) around the optic nerve head (ONH) in a sector-wise manner in eyes with retinitis pigmentosa (RP).

Methods: The present study enrolled the RP patients who demonstrated VF constriction within central 10°. The VD around the ONH was measured with optical coherence tomography angiography (OCTA), using three binarization methods and the relationships between VD and the mean deviation (MD) value were investigated, respectively. Then, the VD in each quadrant (superior, temporal, inferior, nasal) around the ONH was calculated using Otsu method (OVDs: vessel density measured with Otsu method in the superior region, OVDt: vessel density measured with Otsu method in the temporal region, OVDi: vessel density measured with Otsu method in the inferior region, OVDn: vessel density measured with Otsu method in the nasal region). Considering the foveal position relative to the optic disc, angle-corrected binarized OCTA images were created and the VD was measured in each sector (AcOVDs: angle-corrected OVDs, AcOVDt: angle-corrected OVDt, AcOVDi: angle-corrected OVDi, and AcOVDn: angle-corrected OVDn). We investigated the relationship between the MD value and OVDs, OVDt, OVDi and OVDn. Furthermore, the correlation between the MD value and AcOVDs, AcOVDt, AcOVDi and AcOVDn was analyzed.

Results: Thirty-six eyes were examined in the current study. Among Niblack, Bernsen and Otsu methods, the VD measured with Otsu method was closely related to the MD value. Among OVDs, OVDt, OVDi and OVDn, the optimal model for the MD value included OVDt and OVDi. On the other hand, among AcOVDs, AcOVDt, AcOVDi and AcOVDn, the optimal model for the MD value included only AcOVDt.

Conclusions: The sector-wise VD around the ONH reflects VF deficit severity and is a candidate for improving the assessment of VF deterioration in eyes with RP.

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色素性视网膜炎瞳孔乳头周围血管密度测量预测中央视野恶化。

目的：探讨色素性视网膜炎（RP）患者视神经头（ONH）周围血管密度与视野（VF）恶化的关系。方法：本研究纳入了在中央10°范围内表现为室颤收缩的RP患者。采用光学相干断层血管造影（OCTA）测量ONH周围的VD，采用三种二值化方法，分别研究VD与平均偏差（MD）值之间的关系。然后，采用Otsu法计算ONH周围各象限（上、颞、下、鼻）VD （OVDs：上区Otsu法测量血管密度，OVDt：颞区Otsu法测量血管密度，OVDi：下区Otsu法测量血管密度，OVDn：鼻区Otsu法测量血管密度）。考虑到中央凹相对于视盘的位置，创建角度校正的二值化OCTA图像，并测量每个扇区的VD （AcOVDs：角度校正的OVDs， AcOVDt：角度校正的OVDt， AcOVDi：角度校正的OVDi和AcOVDn：角度校正的OVDn）。我们研究了MD值与OVDs、OVDt、OVDi和OVDn之间的关系。进一步分析MD值与AcOVDs、AcOVDt、AcOVDi、AcOVDn的相关性。结果：本研究共检查了36只眼。在Niblack法、Bernsen法和Otsu法中，Otsu法测得的VD与MD值密切相关。在ovd、OVDt、OVDi和OVDn中，MD值的最优模型包括OVDt和OVDi。另一方面，在AcOVDs、AcOVDt、AcOVDi和AcOVDn中，MD值的最优模型只有AcOVDt。结论：ONH周围的扇形VD反映了VF缺陷的严重程度，是改善RP眼VF恶化评估的候选物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.