Veratric acid and zinc: a synergistic approach to accelerated wound healing in rats.

IF 5.3 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-07-23 DOI:10.1007/s10787-025-01857-0

Rumila Afzal, Sidra Kaleem, Aslam Khan, Fareeha Anwar, Umair Ilyas, Alaa S Alhegaili, Mansoor Ali, Sajid Ali

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引用次数: 0

Abstract

Veratric acid, a naturally occurring derivative of benzoic acid present in various plants and fruits, has been reported to possess antioxidant, anti-inflammatory, antimicrobial, and antihypertensive properties. This study was designed to evaluate the effects of veratric acid (VA) and zinc (ZN) on wound healing in rats, assessing their individual (per se) and combined effects to determine the potential for synergistic healing benefits. In an experimental rat model, key variables, including wound closure rate, collagen synthesis, angiogenesis, and inflammation, were assessed in the presence or absence of VA and ZN, both individually and in combination. According to the study's findings, the combination of VA and ZN (10% + 10%) significantly enhances wound healing by promoting collagen synthesis, accelerating angiogenesis (the formation of new blood vessels), and reducing inflammation, thereby facilitating wound closure. The combination of veratric acid and zinc further amplified these effects, indicating a potential synergistic interaction between the two compounds. In the treatment groups, hydroxyproline levels and antioxidant parameters-including catalase, superoxide dismutase, nitric oxide, malondialdehyde, and glutathione-were significantly restored compared to the diseased control group, showing a recovery pattern similar to that of the standard control group. This study aims to provide the therapeutic potential of veratric acid, zinc, and combinations of both. The combination group shows more promising results as compared to their individual effects, indicating synergistic effects. Our data demonstrated a positive effect of the combination group along with the underlying mechanisms, suggesting its clinical potential for wound-healing applications.

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戊三酸和锌：促进大鼠伤口愈合的协同作用。

戊三酸是苯甲酸的天然衍生物，存在于各种植物和水果中，据报道具有抗氧化、抗炎、抗菌和抗高血压的特性。本研究旨在评估戊三酸（VA）和锌（ZN）对大鼠伤口愈合的影响，评估它们单独（单独）和联合作用，以确定潜在的协同愈合益处。在实验大鼠模型中，评估了VA和ZN单独或联合存在或不存在时的关键变量，包括伤口愈合率、胶原合成、血管生成和炎症。研究发现，VA和ZN（10% + 10%）的组合可以通过促进胶原合成，加速血管生成（新血管的形成），减少炎症，从而促进伤口愈合，显著促进伤口愈合。戊二酸和锌的结合进一步增强了这些作用，表明两种化合物之间存在潜在的协同作用。与患病对照组相比，治疗组羟脯氨酸水平和抗氧化参数（包括过氧化氢酶、超氧化物歧化酶、一氧化氮、丙二醛和谷胱甘肽）显著恢复，恢复模式与标准对照组相似。本研究旨在提供戊二酸，锌，和两者的组合的治疗潜力。联合用药组比单独用药组显示出更有希望的结果，表明有协同作用。我们的数据显示了联合组的积极效果以及潜在的机制，表明其在伤口愈合应用的临床潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]