The role of lipophagy in liver cancer: mechanisms and targeted therapeutic interventions.

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-07-08 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1562542

Peiyu Han, Han Wang, Yuyu Chen, Yuqiu Ge, Huiting Xu, Hongbo Ren, Yiteng Meng

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Abstract

Liver cancer, the advanced stage of various chronic liver diseases, has garnered attention due to its high incidence and insidious progression. Lipid droplets (LDs), unique lipid storage organelles in hepatocytes, play a pivotal role in lipid metabolism. Lipophagy, a selective autophagy process initially identified in hepatocytes, regulates lipid homeostasis by selectively degrading LDs. This process offers a novel therapeutic avenue for addressing lipid metabolism disorders in liver cancer. This review highlights the regulatory role of lipophagy in liver cancer progression and its therapeutic potential. It elaborates on the molecular mechanisms underlying lipophagy-mediated LDs degradation and discusses the dual regulatory role of lipophagy in liver cancer. While lipophagy can suppress liver cancer development, under specific conditions, it may promote cancer cell proliferation, inhibit apoptosis, facilitate invasion and metastasis, and contribute to treatment resistance. Consequently, strategies targeting lipophagy for liver cancer prevention and therapy hold significant promise. These include interventions through traditional Chinese and Western medicine, as well as lifestyle modifications. This review evaluates current research, hotspots, and controversies in the field, aiming to provide innovative therapeutic strategies for liver cancer associated with abnormal lipid metabolism.

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脂肪吞噬在肝癌中的作用：机制和靶向治疗干预。

肝癌是各种慢性肝脏疾病的晚期，因其发病率高、进展隐匿而备受关注。脂滴是肝细胞中一种独特的脂质储存细胞器，在脂质代谢中起着至关重要的作用。脂噬是一种最初在肝细胞中发现的选择性自噬过程，通过选择性降解ld来调节脂质稳态。这一过程为解决肝癌脂质代谢紊乱提供了一种新的治疗途径。本文综述了脂噬在肝癌进展中的调节作用及其治疗潜力。阐述了脂噬介导ld降解的分子机制，并讨论了脂噬在肝癌中的双重调控作用。虽然噬脂可以抑制肝癌的发展，但在特定条件下，它可能会促进癌细胞增殖，抑制细胞凋亡，促进侵袭和转移，并有助于治疗耐药性。因此，针对脂肪吞噬的肝癌预防和治疗策略具有重要的前景。这些措施包括通过传统的中西医干预，以及改变生活方式。本文综述了该领域的研究现状、热点和争议，旨在为脂质代谢异常相关的肝癌提供创新的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.