Glycerol Bioconversion to Biofuel and Value-Added Products by Yeasts.

IF 2.4 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Kostyantyn Dmytruk, Marta Semkiv, Andriy Sibirny
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引用次数: 0

Abstract

Glycerol, a by-product of biodiesel production, is a versatile polyol used in various industries. Yeasts play a crucial role in converting glycerol into biofuels and value-added products, offering sustainable alternatives to chemical synthesis. This review explores glycerol metabolism in yeasts, focusing on its bioconversion into ethanol, isopropanol, lipids, organic acids, and polyols. Saccharomyces cerevisiae and Yarrowia lipolytica are prominent species for these processes, with metabolic engineering enhancing their efficiency. Ethanol production from crude glycerol, a by-product of the biodiesel industry, is cost-effective compared to traditional feedstocks, while lipid production by oleaginous yeasts supports biodiesel synthesis. Organic acids like succinic, citric, and lactic acids, along with polyols such as erythritol and mannitol, are produced through optimized pathways, achieving high yields. Crude glycerol, despite impurities, is a viable low-cost substrate, with yeast strains adapted to tolerate its contaminants. Challenges include improving strain tolerance and scaling up processes. Future research aims to refine metabolic engineering and fermentation strategies to maximize glycerol's potential as a renewable feedstock for industrial biotechnology.

甘油转化为生物燃料和酵母的增值产品。
甘油是生物柴油生产的副产品,是一种用途广泛的多元醇,广泛应用于各行各业。酵母在将甘油转化为生物燃料和增值产品方面发挥着至关重要的作用,为化学合成提供了可持续的替代品。本文综述了甘油在酵母中的代谢,重点是其转化为乙醇、异丙醇、脂类、有机酸和多元醇。酿酒酵母菌和多脂耶氏菌是这些过程的重要物种,代谢工程可以提高它们的效率。与传统原料相比,生物柴油工业的副产品粗甘油生产乙醇具有成本效益,而产油酵母生产脂质支持生物柴油的合成。琥珀酸、柠檬酸和乳酸等有机酸,以及赤藓糖醇和甘露醇等多元醇,通过优化的途径生产,产量很高。尽管含有杂质,但粗甘油是一种可行的低成本底物,酵母菌株适应其污染物。挑战包括提高应变容限和扩大工艺规模。未来的研究旨在完善代谢工程和发酵策略,以最大限度地发挥甘油作为工业生物技术可再生原料的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEMS yeast research
FEMS yeast research 生物-生物工程与应用微生物
CiteScore
5.70
自引率
6.20%
发文量
54
审稿时长
1 months
期刊介绍: FEMS Yeast Research offers efficient publication of high-quality original Research Articles, Mini-reviews, Letters to the Editor, Perspectives and Commentaries that express current opinions. The journal will select for publication only those manuscripts deemed to be of major relevance to the field and generally will not consider articles that are largely descriptive without insights on underlying mechanism or biology. Submissions on any yeast species are welcome provided they report results within the scope outlined below and are of significance to the yeast field.
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