{"title":"LINC-PINT: A Distinctive Long Non-Coding RNA Functioning as a Potential Suppressor in Tumorigenesis.","authors":"Jiayi Li, Yining Pan, Songqiang Li, Cheng Chen, Chengfu Yuan","doi":"10.2174/0115680266372915250716225540","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Long noncoding RNAs are essential regulators in numerous biological processes and have been linked to various diseases, including cancer. Despite their initial classification as transcriptional byproducts, lncRNAs have been shown to modulate chromatin structure, transcription, RNA processing, protein translation, and intranuclear transport. LINC-PINT, a lncRNA induced by P53, is particularly noteworthy for its role in tumor suppression across multiple cancers.</p><p><strong>Methods: </strong>By utilizing the PubMed database and applying inclusion criteria based on relevance, literature quality, and data availability, we conducted a comprehensive analysis of 128 studies to provide an overview of the functions of LINC-PINT and its mechanisms of action in cancers.</p><p><strong>Results: </strong>LINC-PINT was confirmed to function as a tumor suppressor factor in many cancers, such as triple-negative breast cancer, non-small cell lung cancer, gastric cancer, glioma, melanoma, osteosarcoma, laryngeal squamous cell carcinoma, esophageal cancer, colorectal cancer, nasopharyngeal carcinoma, retinoblastoma, ovarian cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer by promoting apoptosis and senescence, inhibiting proliferation, migration, invasion, drug resistance, cell stemness, EMT, radioresistance, and DNA damage repair.</p><p><strong>Discussion: </strong>LINC-PINT serves as a tumor suppressor with its ability to sponge miRNAs, regulate epigenetic modulation, DNA damage repair, etc. Despite the promising findings, the complex and tissue-specific functions of LINC-PINT, along with the need for further clinical validation, underscore the importance of continued research to fully understand its mechanisms and potential as a therapeutic target.</p><p><strong>Conclusion: </strong>LINC-PINT is a potential target in cancer progression and treatment.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266372915250716225540","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Long noncoding RNAs are essential regulators in numerous biological processes and have been linked to various diseases, including cancer. Despite their initial classification as transcriptional byproducts, lncRNAs have been shown to modulate chromatin structure, transcription, RNA processing, protein translation, and intranuclear transport. LINC-PINT, a lncRNA induced by P53, is particularly noteworthy for its role in tumor suppression across multiple cancers.
Methods: By utilizing the PubMed database and applying inclusion criteria based on relevance, literature quality, and data availability, we conducted a comprehensive analysis of 128 studies to provide an overview of the functions of LINC-PINT and its mechanisms of action in cancers.
Results: LINC-PINT was confirmed to function as a tumor suppressor factor in many cancers, such as triple-negative breast cancer, non-small cell lung cancer, gastric cancer, glioma, melanoma, osteosarcoma, laryngeal squamous cell carcinoma, esophageal cancer, colorectal cancer, nasopharyngeal carcinoma, retinoblastoma, ovarian cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer by promoting apoptosis and senescence, inhibiting proliferation, migration, invasion, drug resistance, cell stemness, EMT, radioresistance, and DNA damage repair.
Discussion: LINC-PINT serves as a tumor suppressor with its ability to sponge miRNAs, regulate epigenetic modulation, DNA damage repair, etc. Despite the promising findings, the complex and tissue-specific functions of LINC-PINT, along with the need for further clinical validation, underscore the importance of continued research to fully understand its mechanisms and potential as a therapeutic target.
Conclusion: LINC-PINT is a potential target in cancer progression and treatment.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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