Fixation of surface microarchitecture for interbody fusion devices under spondylolisthesis loading conditions

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-07-21 DOI:10.1016/j.clinbiomech.2025.106631

Nicholas G. Lamb , Sophia N. Sangiorgio , Matt Zoghi , Eddie Ebramzadeh , John R. Ehteshami

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引用次数: 0

Abstract

Background

Initial stability between a lumbar fusion cage and the vertebral endplates, particularly under the adverse loading conditions characteristic of spondylolisthesis, is vital for osseointegration and fusion. The aim of this study was to compare fixation strength and stability of surface microarchitecture designs of interbody fusion devices under shear loading in synthetic bone as a function of bone density and sagittal inclination.

Methods

Two surface design parameters were evaluated, serration height and pattern (1 mm-triangle 2 mm-triangle, and 2 mm-wedge serration patterns), under 30° and 45° of sagittal inclination. Each surface design and inclination combination was tested in three types of bone quality simulated using polyurethane foam with varying density and porosity.

Findings

Overall, sagittal migration and cyclic micromotion of the 2 mm wedge design were significantly larger than the other surface designs. Sagittal migration was 68 % to 95 % greater for the 2 mm-wedge design at similar forces, and 28 % to 63 % greater in cyclic micromotion. These differences were less pronounced when inclination was increased and/or bone density was decreased.

Interpretations

The results of this study indicated that surface serrations with tips closer aligned to the direction of shear force at the endplate, such as the wedge design, lead to greater migration and micromotion. Among the factors investigated, total sagittal migration was more heavily impacted by surface microarchitecture than micromotion and maximum force. Surface microarchitecture had a smaller effect on stability than bone density under higher inclination. Therefore, differences in bone quality and inclination are important considerations when selecting or designing interbody fusion devices.

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滑脱载荷条件下椎间融合装置表面微结构的固定

背景腰椎融合器与椎体终板之间的初始稳定性，特别是在腰椎滑脱的不利载荷条件下，对骨融合和融合至关重要。本研究的目的是比较合成骨剪切载荷下椎间融合装置表面微结构设计的固定强度和稳定性与骨密度和矢状倾角的关系。方法在矢状面倾角为30°和45°的情况下，评价2个曲面设计参数：锯齿高度和锯齿样式（1 mm-三角形、2 mm-三角形和2 mm-楔形）。采用不同密度和孔隙率的聚氨酯泡沫模拟了三种骨质量，测试了每种表面设计和倾角组合。总的来说，2 mm楔形设计的矢状迁移和循环微动明显大于其他表面设计。在相同的力下，2毫米楔形设计的矢状偏移量增加68%至95%，在循环微运动中增加28%至63%。当倾斜度增加和/或骨密度降低时，这些差异不那么明显。本研究的结果表明，尖端与端板剪切力方向更接近的表面锯齿，如楔形设计，会导致更大的迁移和微运动。在研究的因素中，表面微结构比微运动和最大力对总矢状位迁移的影响更大。在高倾角下，表面微结构对稳定性的影响小于骨密度。因此，在选择或设计椎间融合装置时，骨质量和倾斜度的差异是重要的考虑因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.