Screening hemodialysis patients for tuberculosis in Sudan

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-07-01 DOI:10.1016/j.ijtb.2024.08.013

Sarra Elamin , Selma S. Ibrahim, Hytham AD El-Mahdi, Amel Kailani, Shaza AM Mohamednour, Salma NA Mohamed, Tagwa MA Osman, Mohamed AA Abdulla, Sofyan MM Babiker, Hassan MAH Abubaker, May AO Suleiman

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引用次数: 0

Abstract

Objectives

To estimate the prevalence of latent tuberculosis infection (LTBI) and the need for TB preventive treatment (TPT) among hemodialysis (HD) patients in Sudan.

Methods

We screened patients in a single HD center by two-step tuberculin skin test (TST), symptom survey, physical examination and chest radiography (CXR).

Results

The survey included 204 patients, five of whom (2.5%) had history of previously treated TB. The proportion of TST positive patients was 12.3% after the first test and increased to 21.1% after the second test. Patients previously treated for TB were more likely to have positive TST (80 vs 20.1%, p = 0.01). We screened 184 patients for TB disease; 16.3% were symptomatic, 15.8% had CXR abnormality and 6.5% were symptomatic with CXR abnormality. Additionally, 13.6% of patients had physical signs consistent with extra-pulmonary TB without symptoms or CXR abnormality. Based on these findings, high probability of pulmonary and extra-pulmonary TB was found in 38.6% and 13.6% of patients respectively and they were referred for bacteriological confirmation. We diagnosed LTBI and prescribed TPT to 9.2% of screened patients.

Conclusion

In this cohort of Sudanese HD patients, 21.1% were positive after two-step TST and 52.2% were considered to have high probability of TB disease.

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苏丹血液透析患者肺结核筛查

目的了解苏丹血液透析（HD）患者的潜伏性结核感染（LTBI）患病率和结核病预防治疗（TPT）需求。方法采用两步结核菌素皮肤试验（TST）、症状调查、体格检查和胸部x线摄影（CXR）筛查单一中心的患者。结果本次调查共纳入204例患者，其中5例（2.5%）有既往结核治疗史。第一次检测TST阳性患者比例为12.3%，第二次检测TST阳性患者比例为21.1%。以前接受过结核病治疗的患者更有可能出现TST阳性（80% vs 20.1%, p = 0.01）。我们筛查了184名结核病患者；有症状者占16.3%，有CXR异常者占15.8%，有症状者占6.5%。此外，13.6%的患者有符合肺外结核的体征，无症状或CXR异常。基于这些结果，38.6%和13.6%的患者分别发现高概率肺结核和肺外结核，并将其转诊进行细菌学确认。我们诊断为LTBI，并对9.2%的筛查患者开TPT。结论在该苏丹HD患者队列中，两步TST阳性率为21.1%，52.2%为高概率结核病患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline