Characterization of psychiatric admissions in Huntington disease: A retrospective review

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-07-21 DOI:10.1016/j.jpsychores.2025.112331

Shuhei Shiino , Sarah Moroz , Jeffrey Stovall , William M. Petrie , Daniel O. Claassen , Katherine E. McDonell

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Abstract

Objective

Neuropsychiatric symptoms are common clinical features of Huntington disease (HD) that can result in mental health emergencies. However, there are no established guidelines for inpatient psychiatric treatment in HD. In this study, the investigators reviewed psychiatric hospitalizations in a large medical center to better understand the mental health needs of patients with HD and identify potential gaps in care.

Methods

Charts were reviewed to identify patients with HD at Vanderbilt University Medical Center who were admitted to psychiatry between 2013 and 2020. Clinical data and demographic information were obtained from the electrical health record along with the indication for each psychiatric admission, actions taken during the admission, and follow-up care.

Results

Among this cohort, 32 of 287 patients (11.1 %) were admitted to inpatient psychiatry at least once. Age at first admission ranged from 17 to 74 years, with 84.4 % of patients in the motor-manifest stage. The most common reasons for admission were suicidal ideation or attempt (57.6 %), psychosis (39.4 %), and aggression (36.4 %). Most patients were able to return to their previous level of care, although readmissions were common.

Conclusions

These results emphasize the frequency and severity of psychiatric crises in HD and support the need for expanded access to emergency psychiatry care across the disease course. Further research is warranted to develop an integrated, disease-specific approach to early recognition and management of psychiatric symptoms in HD.

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亨廷顿病精神病入院特征：回顾性回顾

目的神经精神症状是亨廷顿病（HD）的常见临床特征，可导致精神卫生紧急事件。然而，对于HD患者的住院精神治疗尚无既定的指导方针。在这项研究中，研究人员回顾了一家大型医疗中心的精神病住院情况，以更好地了解HD患者的心理健康需求，并确定护理方面的潜在差距。方法回顾了2013年至2020年间在范德比尔特大学医学中心（Vanderbilt University Medical Center）入院的HD患者的病历。临床数据和人口统计信息来自电子健康记录，以及每次精神病入院的适应症、入院期间采取的行动和随访护理。结果在该队列中，287例患者中有32例（11.1%）至少住院一次精神科。首次入院年龄17 ~ 74岁，84.4%为运动表现期。最常见的入院原因是自杀意念或企图（57.6%）、精神病（39.4%）和攻击性（36.4%）。大多数患者能够恢复到以前的护理水平，尽管再入院很常见。结论：这些结果强调了HD患者精神危机的频率和严重程度，并支持在整个疾病过程中扩大急诊精神病学护理的必要性。进一步的研究需要开发一种综合的、疾病特异性的方法来早期识别和管理HD患者的精神症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.