Kinetic modeling of blood cells in a turbulent environment and its effect on hemolysis

IF 5.7 1区 工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY
Qilong Lian, Yuan Xiao, Zhanshuo Cao, Lingyu Meng, Guomin Cui
{"title":"Kinetic modeling of blood cells in a turbulent environment and its effect on hemolysis","authors":"Qilong Lian,&nbsp;Yuan Xiao,&nbsp;Zhanshuo Cao,&nbsp;Lingyu Meng,&nbsp;Guomin Cui","doi":"10.1016/j.ijengsci.2025.104349","DOIUrl":null,"url":null,"abstract":"<div><div>Through careful physical modeling, this study provides insight into the effect of forces on hemolysis exerted on blood cells in the viscous subrange of the turbulence spectrum. We constructed a simplified coupling model of eddy currents with blood cells and analyzed it using a membrane tension quantification index directly related to hemolysis. It is found that the membrane tension resulting from blood cell interactions changes the overall ensemble force by an order of magnitude and more, and in some high-energy vortices, even dominates the ensemble force. This finding emphasizes that blood cannot simply be regarded as a dilute flow field in simulating the hemolysis process, but the real mechanical forces exerted on blood cells must be fully considered. Based on these findings, we propose an improved blood cell shear force model, which optimizes the classical Kolmogorov theoretical formulation in the viscous subrange, and by combining the model with the blood cell trajectory equation, we have successfully modified the force environment of blood cells, which makes the simulation results closer to the reality. Under two operating conditions of the FDA blood pump (2.5 L/min, 3500 rpm, 7.0 L/min, 3500 rpm), the turbulent intermittency inside the flow field reaches the maximum effect at multiple Reynolds numbers. The error of the relative hemolysis value calculated by the new model is significantly reduced compared with the original model. The error from the experiments reached less than 8% under multiple computational conditions, demonstrating an excellent prediction ability.</div></div>","PeriodicalId":14053,"journal":{"name":"International Journal of Engineering Science","volume":"216 ","pages":"Article 104349"},"PeriodicalIF":5.7000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Engineering Science","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020722525001363","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Through careful physical modeling, this study provides insight into the effect of forces on hemolysis exerted on blood cells in the viscous subrange of the turbulence spectrum. We constructed a simplified coupling model of eddy currents with blood cells and analyzed it using a membrane tension quantification index directly related to hemolysis. It is found that the membrane tension resulting from blood cell interactions changes the overall ensemble force by an order of magnitude and more, and in some high-energy vortices, even dominates the ensemble force. This finding emphasizes that blood cannot simply be regarded as a dilute flow field in simulating the hemolysis process, but the real mechanical forces exerted on blood cells must be fully considered. Based on these findings, we propose an improved blood cell shear force model, which optimizes the classical Kolmogorov theoretical formulation in the viscous subrange, and by combining the model with the blood cell trajectory equation, we have successfully modified the force environment of blood cells, which makes the simulation results closer to the reality. Under two operating conditions of the FDA blood pump (2.5 L/min, 3500 rpm, 7.0 L/min, 3500 rpm), the turbulent intermittency inside the flow field reaches the maximum effect at multiple Reynolds numbers. The error of the relative hemolysis value calculated by the new model is significantly reduced compared with the original model. The error from the experiments reached less than 8% under multiple computational conditions, demonstrating an excellent prediction ability.
湍流环境中血细胞的动力学建模及其对溶血的影响
通过仔细的物理建模,本研究深入了解了在湍流谱的粘性子范围内施加在血细胞上的溶血力的影响。我们建立了涡流与血细胞的简化耦合模型,并使用与溶血直接相关的膜张力定量指标对其进行了分析。研究发现,由血细胞相互作用引起的膜张力使整体系综力发生了一个数量级以上的变化,在某些高能涡旋中,甚至主导了系综力。这一发现强调了在模拟溶血过程时,不能简单地把血液看作是一个稀释的流场,而必须充分考虑施加在血细胞上的真实机械力。在此基础上,我们提出了一种改进的血细胞剪切力模型,该模型在黏性子范围内对经典Kolmogorov理论公式进行了优化,并将该模型与血细胞轨迹方程相结合,成功地修正了血细胞的受力环境,使模拟结果更接近现实。FDA血泵在2.5 L/min, 3500 rpm, 7.0 L/min, 3500 rpm两种工况下,流场内部湍流间歇性在多个雷诺数时效果最大。与原模型相比,新模型计算的相对溶血值误差明显减小。在多种计算条件下,实验误差小于8%,具有良好的预测能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
International Journal of Engineering Science
International Journal of Engineering Science 工程技术-工程:综合
CiteScore
11.80
自引率
16.70%
发文量
86
审稿时长
45 days
期刊介绍: The International Journal of Engineering Science is not limited to a specific aspect of science and engineering but is instead devoted to a wide range of subfields in the engineering sciences. While it encourages a broad spectrum of contribution in the engineering sciences, its core interest lies in issues concerning material modeling and response. Articles of interdisciplinary nature are particularly welcome. The primary goal of the new editors is to maintain high quality of publications. There will be a commitment to expediting the time taken for the publication of the papers. The articles that are sent for reviews will have names of the authors deleted with a view towards enhancing the objectivity and fairness of the review process. Articles that are devoted to the purely mathematical aspects without a discussion of the physical implications of the results or the consideration of specific examples are discouraged. Articles concerning material science should not be limited merely to a description and recording of observations but should contain theoretical or quantitative discussion of the results.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信