Genetic history of Scythia

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-07-23 DOI:10.1126/sciadv.ads8179

Tatiana V. Andreeva, Anna D. Soshkina, Fedor E. Gusev, Alexandra B. Malyarchuk, Gleb S. Dotsenko, Natalia A. Dudko, Maria Yu. Plotnikova, Svetlana S. Kunizheva, Andrey D. Manakhov, Tatiana V. Ustkachkintseva, Maria S. Protasova, Semyon A. Volodin, Alexandra P. Buzhilova, Yuriy D. Razuvaev, Natalia Ya. Berezina, Yakov B. Berezin, Anatoly R. Kantorovich, Vladimir E. Maslov, Dmitry G. Barinov, Maria V. Dobrovolskaya, Evgeny I. Rogaev

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Abstract

Great Scythia was the ancient Greek name for the area stretching from the northern Black Sea coast to the Middle Don. Using high-quality genomic data generated from 131 ancient individuals from Great Scythia and neighboring regions of the Bronze Age and the Iron Age, we established the genetic structure of the Scythians, revealing their diverse origin with major European Bronze Age ancestral components, and genetic traces of migration and invasions. We uncovered relationships between Scythians, including elite Scythians. Substantial endogamy in the Scythian clan was found. We examined Scythians’ phenotypes and medical-genetic background and found a harmful gene mutation causing fructose intolerance. This ancient “Scythian” mutation has spread throughout West Eurasia and has become the most prevalent genetic cause of fructose intolerance in contemporary European populations.

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Scythia的遗传史

大塞西亚是从黑海北部海岸延伸到顿河中部地区的古希腊名称。利用来自大塞西亚和青铜时代和铁器时代邻近地区的131个古代个体的高质量基因组数据，我们建立了塞西亚人的遗传结构，揭示了他们与欧洲青铜时代主要祖先成分的多样化起源，以及迁移和入侵的遗传痕迹。我们发现了斯基泰人之间的关系，包括精英斯基泰人。在斯基泰氏族中发现了大量的内婚制。我们检查了Scythians的表型和医学遗传背景，发现了导致果糖不耐受的有害基因突变。这种古老的“斯基泰人”突变已经传播到欧亚大陆西部，并成为当代欧洲人群中果糖不耐受最普遍的遗传原因。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.