Green and Safe Straightforward Coupling of Anhydrides to Ketones and Biphenyls in Quartz Sand Medium.

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-07-23 DOI:10.1021/acs.joc.5c00293

Zujia Lu,Baoying Huang,Guangzao Yang,Minjie Gao,Tingting Liu,Fei Wang,Zhuo Zeng

引用次数: 0

Abstract

We present a sustainable and safe method for synthesizing aromatic ketones and biphenyls using quartz sand as a green medium. Quartz sand replaces traditional solvents, providing a safer, eco-friendly alternative in Suzuki-Miyaura coupling and decarbonylative coupling reactions. The Suzuki-Miyaura coupling reactions occur under mild, solvent-free conditions with efficient synthesis and easy purification. Both quartz sand and catalyst are reusable, highlighting the method's resource efficiency and environmental sustainability. Biphenyls are produced via ligand- and copper salt-assisted decarbonylative coupling.

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石英砂介质中酸酐与酮类和联苯的绿色安全直接偶联。

提出了一种可持续、安全的以石英砂为绿色介质合成芳香酮和联苯的方法。石英砂取代了传统的溶剂，为Suzuki-Miyaura偶联和脱碳偶联反应提供了更安全、环保的替代品。Suzuki-Miyaura偶联反应在温和、无溶剂的条件下进行，合成效率高，纯化容易。石英砂和催化剂都是可重复使用的，突出了该方法的资源效率和环境可持续性。联苯是通过配体和铜盐辅助脱羰偶联产生的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.