Analysis of the diagnostic value of preoperative blood indicators NLR, PLR and AAR in cervical lymph node metastasis of head and neck squamous cell carcinoma.

IF 2.2 3区医学 Q2 Dentistry

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-07-19 DOI:10.1016/j.jormas.2025.102504

Ningchang Zhu, Jin Yang, Jun Sun, Yingying Jiang, Jiwei Zheng

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引用次数: 0

Abstract

Objective: This study aims to evaluate the clinical significance of preoperative blood test indicators in diagnosing cervical lymph node metastasis in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: A total of 97 HNSCC patients who underwent surgical treatment at the Affiliated Hospital of Xuzhou Medical University between October 2023 and January 2025 were included in the study. Based on postoperative pathological results, the patients were categorized into two groups: those with cervical lymph node metastasis and those without. Preoperative blood routine examination indicators, including neutrophils, platelets, and lymphocytes, as well as biochemical examination indicators such as aspartate aminotransferase and albumin, were collected. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and aspartate aminotransferase-to-albumin ratio (AAR) were calculated. The diagnostic value of preoperative NLR, PLR and AAR for cervical lymph node metastasis in HNSCC patients was subsequently analyzed.

Results: The NLR and AAR values in the cervical lymph node metastasis group were significantly higher than those in the non-cervical lymph node metastasis group. The optimal cut-off values and areas under the curve for NLR and AAR in diagnosing cervical lymph node metastasis among patients with HNSCC were 0.687 and 0.682 for NLR, and 3.3433 and 0.6338 for AAR, respectively. Results from multivariate logistic regression analysis indicated that AAR may serve as a potential blood indicator for evaluating cervical lymph node metastasis in HNSCC patients.

Conclusion: Preoperative NLR, PLR and AAR have significant clinical value for the initial screening and diagnosis of lymph node metastasis in HNSCC.

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术前血液指标NLR、PLR、AAR对头颈部鳞状细胞癌颈部淋巴结转移的诊断价值分析

目的：探讨术前血液检查指标在头颈部鳞状细胞癌（HNSCC）患者颈部淋巴结转移诊断中的临床意义。方法：选取2023年10月至2025年1月在徐州医科大学附属医院行手术治疗的HNSCC患者97例为研究对象。根据术后病理结果将患者分为宫颈淋巴结转移组和无淋巴结转移组。收集术前血常规检查指标，包括中性粒细胞、血小板、淋巴细胞，以及天冬氨酸转氨酶、白蛋白等生化检查指标。计算中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和天冬氨酸转氨酶与白蛋白比值（AAR）。分析术前NLR、PLR、AAR对HNSCC颈部淋巴结转移的诊断价值。结果：颈淋巴转移组NLR和AAR值明显高于非颈淋巴转移组。NLR和AAR诊断HNSCC颈部淋巴结转移的最佳截断值和曲线下面积分别为0.687和0.682，AAR为3.3433和0.6338。多因素logistic回归分析结果提示，AAR可作为评估HNSCC患者颈部淋巴结转移的潜在血液指标。结论：术前NLR、PLR和AAR对HNSCC淋巴结转移的初步筛查和诊断具有重要的临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.