Interplay between attention-deficit/hyperactivity disorder, educational attainment, and vascular risk factors: Insights from Mendelian randomization analyses.
Jiahao Song, Da Zhou, Haiyue Zhang, Jingrun Li, Chuanjie Wu, Lili Cui, Haiqing Song, Xunming Ji, Lina Jia, Ran Meng
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引用次数: 0
Abstract
The causal relationships between attention-deficit/hyperactive disorder (ADHD) and vascular risk factors remain insufficiently understood. This study aimed to comprehensively investigate the causal effects of ADHD on vascular risk factors and identify crucial mediators in these relationships. Utilizing instrumental variables from genome-wide association study (GWAS) datasets, we applied two-sample Mendelian randomization (MR) to explore the causal influences of ADHD on adiposity-related traits, blood pressure regulation, glucose metabolism, lipid profiles, lifestyle habits, chronic kidney disease, and systemic inflammation. Additionally, two-step MR was employed to evaluate the mediating effect of educational attainment (EA) in each newly established causal pair. Genetically determined ADHD was causally linked to increased body mass index (BMI, β = 0.054, p = 1.01E-08), waist-to-hip ratio (WHR, β = 0.041, p = 1.65E-07), waist circumference (WC, β = 0.048, p = 5.78E-15), body fat percentage (BF%, β = 0.024, p = 7.19E-05), risk of type-2 diabetes mellitus (T2DM, OR = 1.104, p = 6.07E-07), and number of cigarettes smoked per day (β = 0.094, p = 3.99E-06), earlier smoking initiation (β = 0.115, p = 2.71E-12), and higher levels of C-reactive protein (CRP, β = 0.054, p = 6.35E-14). Furthermore, EA was demonstrated to play a key mediating role in these causal relationships, with mediation proportions ranging from 41.67% to 11.30%. Our MR analyses supported the causal impacts of ADHD on several vascular risk factors, including BMI, WHR, WC, BF%, T2DM, early smoking initiation, cigarettes consumed per day, and CRP. Moreover, we recognized EA as a critical mediator underlying the established causal pathways. Overall, this study highlighted that individuals with ADHD were more likely to suffer from obesity, T2DM, poor lifestyle habits, and intense inflammation.
期刊介绍：
The Journal of General Psychology publishes human and animal research reflecting various methodological approaches in all areas of experimental psychology. It covers traditional topics such as physiological and comparative psychology, sensation, perception, learning, and motivation, as well as more diverse topics such as cognition, memory, language, aging, and substance abuse, or mathematical, statistical, methodological, and other theoretical investigations. The journal especially features studies that establish functional relationships, involve a series of integrated experiments, or contribute to the development of new theoretical insights or practical applications.
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