B cell mechanotransduction via ATAT1 coordinates actin and lysosomal dynamics at the immune synapse.

Abstract

In this issue, (Aceitón et al. https://doi.org/10.1083/jcb.202407181) uncover a pathway that ties together rigidity sensing at the B cell immunological synapse to molecular shuttling of ATAT1, leading to microtubule acetylation and lysosome repositioning, ultimately tuning the efficiency of antigen uptake and presentation by B cells.