Association between selective serotonin reuptake inhibitors and the periodontal status: a systematic review and meta-analysis of observational clinical studies.

IF 2.3 Q3 Dentistry

Evidence-based dentistry Pub Date : 2025-07-22 DOI:10.1038/s41432-025-01179-8

Liana Rita Nicole Umbrio, Hieu Michael Pham, Abdul B Barmak, Nasser Assery, Elli Anna Kotsailidi

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引用次数: 0

Abstract

Aims: To evaluate the effect of selective serotonin reuptake inhibitors (SSRIs) on periodontal status through a systematic review and meta-analysis.

Methods: Nine databases were searched for clinical studies up to September 2024 to identify clinical studies comparing periodontal parameters such as probing depth (PD), clinical attachment level (CAL), marginal bone level (MBL), and gingival and plaque indices (GI and PI) between SSRI-users and non-users. Study selection, data extraction, and risk of bias assessment were performed independently by two authors. Random-effects meta-analyses of mean differences (MD) were performed. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to assess the quality of available evidence.

Results: Five cross-sectional studies, including a total of 1254 patients (54.15% females) and 13170 teeth, were included. The use of SSRIs was significantly associated with inferior MBL (MD, 0.10; 95% confidence interval, 0.01 to 0.20) compared to non-users. No significant differences were observed in PD, CAL, and GI between SSRI-users and non-users. The overall quality of evidence was low, and all studies presented a moderate risk of bias.

Conclusions: Based on a low level of available scientific evidence, the use of SSRIs has a marginal yet significant effect on MBL. However, there is no direct association between SSRIs usage and periodontal parameters such as PD, CAL, and GI. Nonetheless, further research is warranted.

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选择性血清素再摄取抑制剂与牙周状况的关系：观察性临床研究的系统回顾和荟萃分析。

目的：通过系统回顾和荟萃分析，评价选择性5 -羟色胺再摄取抑制剂（SSRIs）对牙周状态的影响。方法：检索截至2024年9月的9个数据库的临床研究，确定ssri使用者和非ssri使用者的牙周参数，如探探深度（PD）、临床附着水平（CAL）、边缘骨水平（MBL）、牙龈和菌斑指数（GI和PI）的临床研究。研究选择、数据提取和偏倚风险评估由两位作者独立完成。对平均差异（MD）进行随机效应荟萃分析。建议分级评估、发展和评价方法用于评估现有证据的质量。结果：共纳入5项横断面研究，共1254例患者（女性54.15%），13170颗牙。ssri类药物的使用与较差的MBL显著相关(MD, 0.10；95%置信区间，0.01至0.20)。ssri使用者和非ssri使用者在PD、CAL和GI方面没有显著差异。证据的总体质量较低，所有研究均存在中等偏倚风险。结论：基于现有的低水平科学证据，使用SSRIs对MBL有边际但显著的影响。然而，SSRIs的使用与牙周参数如PD、CAL和GI之间没有直接联系。然而，进一步的研究是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Evidence-based dentistry Dentistry-Dentistry (all)

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Evidence-Based Dentistry delivers the best available evidence on the latest developments in oral health. We evaluate the evidence and provide guidance concerning the value of the author''s conclusions. We keep dentistry up to date with new approaches, exploring a wide range of the latest developments through an accessible expert commentary. Original papers and relevant publications are condensed into digestible summaries, drawing attention to the current methods and findings. We are a central resource for the most cutting edge and relevant issues concerning the evidence-based approach in dentistry today. Evidence-Based Dentistry is published by Springer Nature on behalf of the British Dental Association.