Long-term outcome of grade 1 rectal neuroendocrine tumor ≤1 cm after incomplete endoscopic resection.

IF 2.1 Q3 GASTROENTEROLOGY & HEPATOLOGY

Clinical Endoscopy Pub Date : 2025-07-22 DOI:10.5946/ce.2025.043

Jong Sun Park, Hye Lynn Jeon, Bumhee Park, Jong Hoon Park, Gil Ho Lee, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Choong-Kyun Noh

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Abstract

Background/aims: Surveillance strategies for small grade 1 rectal neuroendocrine tumors (G1 rNETs) after incomplete endoscopic resection (ER) remain controversial. We evaluated the long-term outcomes of patients with G1 rNET ≤1 cm after ER who did and did not undergo complete resection.

Methods: We retrospectively evaluated 441 patients with G1 rNETs measuring ≤1 cm after ER between 2011 and 2022. Patients were divided into complete and incomplete resection groups according to histopathological evaluation. Logistic regression analysis identified the risk factors for incomplete resection after ER.

Results: The mean follow-up intervals were 38.6 and 45.7 months in all patients and the incomplete resection group, respectively. No recurrences were observed during the follow-up period. The mean lesion size was 5.5 mm and the complete resection rate was 80.5% (n=355). In the logistic regression analysis, lesion size 5.1 to 10 mm (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.245-4.203; p=0.008), multiple lesions (OR, 8.3; 95% CI, 1.247-54.774; p=0.029), and retroflexion view during the procedure (OR, 4.0; 95% CI, 1.668-9.615; p=0.002) were independent risk factors for incomplete resection.

Conclusions: The prognosis of G1 rNET ≤1 cm after ER was very good, regardless of the histopathological results.

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1级直肠神经内分泌肿瘤≤1cm后不完全内镜切除的远期预后。

背景/目的：不完全内镜切除（ER）后小的1级直肠神经内分泌肿瘤（G1 rNETs）的监测策略仍然存在争议。我们评估了接受和未接受完全切除的ER后G1 rNET≤1cm患者的长期预后。方法：我们回顾性评估了2011年至2022年间441例ER术后G1 rNETs≤1cm的患者。根据组织病理学评价将患者分为完全切除组和不完全切除组。Logistic回归分析确定了ER术后不完全切除的危险因素。结果：所有患者和不完全切除组的平均随访时间分别为38.6个月和45.7个月。随访期间未见复发。平均病灶大小为5.5 mm，全切率为80.5% （n=355）。在logistic回归分析中，病变大小为5.1 ~ 10mm(优势比[OR]， 2.3；95%置信区间[CI]， 1.245-4.203；p=0.008)，多发病变(OR, 8.3；95% ci, 1.247-54.774；p=0.029)，手术过程中的前倾视图(OR, 4.0；95% ci, 1.668-9.615；P =0.002)是不完全切除的独立危险因素。结论：不论组织病理学结果如何，ER术后G1 rNET≤1cm预后良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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