Jose Manuel Noguera Bazan, Layse Ribeiro de Sousa Carvalho, Lucas Dos Santos Silva, Arlindo Ribeiro da Silva Neto, Sergio Murilo da Silva Braga Martins, Luis Claudio Nascimento da Silva
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引用次数: 0
Abstract
Introduction/objective: The limitations of conventional drug delivery methods, such as systemic side effects and poor absorption, highlight the need for safer and more effective alternatives. Polysaccharides, due to their biocompatible, biodegradable, and mucoadhesive properties, have shown promise in formulations for the oral cavity, particularly in localized delivery systems and tissue regeneration. This study aims to conduct a bibliometric analysis to characterize the scientific output on the use of polysaccharides in the oral cavity, identifying trends, international collaborations, and research gaps.
Methods: A Web of Science search was conducted in January 2025 using keywords related to polysaccharides and mucosal adhesion. The analysis included original articles published in English between 2015 and 2024. Bibliometric data and study characteristics were extracted and analyzed, focusing on study types, formulation types, and international collaborations.
Results: The analysis included 66 articles with 1144 citations. In vitro studies were predominant, while clinical trials were lacking. Chitosan and alginate emerged as the most commonly used polysaccharides, with gels and hydrogels being the most prevalent formulations. International collaborations involved 28 countries, with China, Brazil, and Italy standing out in terms of scientific production.
Discussion: The results highlight important advancements in the use of polysaccharides for oral cavity formulations, particularly in gels and hydrogels. However, the predominance of in vitro studies and the lack of clinical trials suggest limitations for translating these findings into clinical practice. The strong performance of countries such as China, Brazil, Italy, Spain, and Norway underscores the relevance of international collaborations and the global potential of this topic.
Conclusion: The increasing scientific output reflects the growing interest in the use of polysaccharides for oral health applications. Despite these advancements, critical gaps remain, such as the lack of clinical studies. Future research should prioritize translational studies, personalized therapies, and the sustainable development of biomaterials.
简介/目的：传统给药方法的局限性，如全身副作用和吸收不良，强调需要更安全、更有效的替代方法。多糖由于其生物相容性、可生物降解性和黏附性，在口腔制剂中，特别是在局部给药系统和组织再生中显示出前景。本研究旨在进行文献计量分析，以表征口腔中多糖使用的科学产出，确定趋势，国际合作和研究差距。方法：于2025年1月在Web of Science检索多糖和粘膜粘附相关关键词。该分析包括2015年至2024年间发表的英文原创文章。对文献计量数据和研究特征进行了提取和分析，重点是研究类型、配方类型和国际合作。结果：纳入文献66篇，被引1144次。体外研究占主导地位，缺乏临床试验。壳聚糖和海藻酸盐是最常用的多糖，凝胶和水凝胶是最常用的配方。国际合作涉及28个国家，其中中国、巴西和意大利在科学生产方面表现突出。讨论：结果强调了在口腔制剂中使用多糖的重要进展，特别是在凝胶和水凝胶中。然而，体外研究的优势和临床试验的缺乏表明，将这些发现转化为临床实践存在局限性。中国、巴西、意大利、西班牙和挪威等国的强劲表现凸显了国际合作的相关性和这一主题的全球潜力。结论：越来越多的科研成果反映了人们对多糖在口腔保健方面的应用越来越感兴趣。尽管取得了这些进展，但仍然存在重大差距，例如缺乏临床研究。未来的研究应优先考虑转化研究、个性化治疗和生物材料的可持续发展。
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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